Double-heater-wire circuits and heat-and-moisture exchangers and the risk of ventilator-associated pneumonia

Critical Care Medicine
R J BootsRichard F Heller

Abstract

To compare the incidence of ventilator-associated pneumonia (VAP) in patients ventilated in intensive care by means of circuits humidified with a hygroscopic heat-and-moisture exchanger with a bacterial viral filter (HME) or hot-water humidification with a heater wire in both inspiratory and expiratory circuit limbs (DHW) or the inspiratory limb only (SHW). A prospective, randomized trial. A metropolitan teaching hospital's general intensive care unit. Three hundred eighty-one patients requiring a minimum period of mechanical ventilation of 48 hrs. Patients were randomized to humidification with use of an HME (n=190), SHW (n=94), or DHW (n=97). Study end points were VAP diagnosed on the basis of Clinical Pulmonary Infection Score (CPIS) (), HME resistance after 24 hrs of use, endotracheal tube resistance, and HME use per patient. VAP occurred with similar frequency in all groups (13%, HME; 14%, DHW; 10%, SHW; p=0.61) and was predicted only by current smoking (adjusted odds ratio [AOR], 2.1; 95% confidence interval [CI], 1.1-3.9; p=.03) and ventilation days (AOR, 1.05; 95% CI, 1.0-1.2; p=.001); VAP was less likely for patients with an admission diagnosis of pneumonia (AOR, 0.40; 95% CI, 0.4-0.2; p=.04). HME resistance after 24 h...Continue Reading

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