Double-illumination photoacoustic microscopy.

Optics Letters
Junjie YaoLihong V Wang

Abstract

Recent developments of optical-resolution photoacoustic microscopy (OR-PAM) have improved its spatial resolution and imaging speed. However, the penetration depth of OR-PAM is still limited to ~1 mm in tissue, owing to the strong tissue scattering. Here, we have developed double-illumination PAM (DI-PAM), which illuminates the sample from both top and bottom sides simultaneously. Through phantom and in vivo experiments, we have demonstrated for thin targets that DI-PAM has a penetration depth of ~2 mm in tissue at 532 nm and a focal zone of 260 μm, both significant improvements over traditional reflection or transmission-mode OR-PAM.

References

Jul 11, 2006·Nature Biotechnology·Hao F ZhangLihong V Wang
May 3, 2008·Optics Letters·Konstantin MaslovLihong V Wang
Jun 17, 2009·Optics Letters·Zhixing XieCarmen A Puliafito
Jan 26, 2011·Optics Letters·Lidai WangLihong V Wang
Aug 3, 2011·Journal of Biomedical Optics·Junjie YaoLihong V Wang
Oct 26, 2011·Contrast Media & Molecular Imaging·Junjie Yao, Lihong V Wang

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Citations

Feb 16, 2013·Chemical Reviews·Anthony S StenderNing Fang
Jan 22, 2013·Journal of Pediatric Surgery·Brad W Warner
Jan 15, 2014·Laser & Photonics Reviews·Junjie Yao, Lihong V Wang
Dec 12, 2012·Journal of Biomedical Optics·Junjie YaoLihong V Wang
Oct 11, 2014·Photoacoustics·Junjie Yao, Lihong V Wang
Apr 7, 2017·Optics Express·Xiaoquan YangQingming Luo
Oct 25, 2016·Journal of Biomedical Optics·Li LinLihong V Wang
May 23, 2012·Chembiochem : a European Journal of Chemical Biology·Stephen R Grobmyer, Huabei Jiang
Apr 19, 2016·Journal of Biomedical Optics·Yong ZhouLihong V Wang
Jul 26, 2018·Scientific Reports·Wei LiuJunjie Yao
Jan 4, 2019·Biomedical Engineering Letters·Wei Liu, Junjie Yao
Nov 19, 2020·Journal of Biophotonics·Mingsheng LiLidai Wang
Dec 29, 2020·Physics in Medicine and Biology·Dhiman DasManojit Pramanik

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