PMID: 9536282Apr 16, 1998Paper

Double immunostaining for p53 and molecular chaperone hsp72/73 in gastric carcinoma

Molecular Pathology : MP
M A VillasecaP Flores

Abstract

To examine the relation between the expression of p53 protein and the chaperone heat shock protein (hsp)72/73 in a population at high risk for gastric carcinoma, using single and double immunohistochemistry, and to compare the expression of these two proteins with clinicopathological features. Monoclonal antibodies were used to investigate the expression of p53 protein and hsp72/73 in 46 human gastric carcinomas. A double immunohistochemical technique was used in cases that showed p53/hsp72/73 coexpression. p53 immunoreactivity was present in 11 tumours (24%), and hsp72/73 immunostaining was observed in 22 cases (48%). p53 expression was observed as nuclear staining in tumoral cells. hsp72/73 expression was demonstrated mainly as cytoplasmic staining, but six tumours also showed focal weak nuclear staining. Seven cases showed p53 and hsp72/73 coexpression with immunoreactivity for both proteins in the same neoplastic cells, three of them with focal areas of nuclear coexpression. p53 expression was seen more frequently in cases that showed a high intensity (+ + +) of hsp72/73 staining. No significant association was observed between the expression of the two proteins and clinicopathological features. More than half of our cases ...Continue Reading

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Citations

Apr 28, 2007·The Tohoku Journal of Experimental Medicine·Xiao-Ping WangXiao-Ping Ying
Dec 26, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Xiaoping WangYixin Yang
Jun 15, 2007·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·T HamamotoM Watanabe

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