Abstract
Anemia and renal insufficiency impart an increased risk of mortality in patients with congestive heart failure. There is a paucity of data on the mortality hazard associated with anemia and renal insufficiency in patients undergoing percutaneous coronary intervention in the setting of contemporary practice. We analyzed the short- and long-term outcomes among patients enrolled in EPIC, EPILOG and EPISTENT trials according to degree of kidney dysfunction (glomerular filtration rate [GFR] <60, 60 to 75, and >75 ml/min/1.73 m2) and by hematocrit (<35, 35 to 39 and 40). GFR was calculated as GFR = 186 x (serum creatinine-1.154) x (age-0.203) x 1.212 (if black) or x 0.742 (if female). There were 20 deaths (3.2%) among 638 patients with a hematocrit of <35, 41 deaths among 2,066 patients (2.0%) with a hematocrit of 35 to 39, and 43 deaths in 3,618 patients (1.2%) with a hematocrit >40 at 6 months (p <0.001). Similarly, a significant increase in mortality was seen with lower GFR [33 of 1,168 (2.9%) at GFR <60, 33 of 1,766 (1.9%) at GFR 60 to 75 and 37 of 3,317 (1.1%) at GFR >75, p <0.001)]. Further, GFR and anemia independently and in combination predicted mortality at 3 years. Thus, renal insufficiency and anemia are significant indep...Continue Reading
References
Jul 1, 1995·Journal of the American Society of Nephrology : JASN·F KronenbergH Dieplinger
Dec 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·W F Keane, A J Collins
Apr 7, 1994·The New England Journal of Medicine·UNKNOWN EPIC Investigators
Jun 12, 1997·The New England Journal of Medicine·UNKNOWN EPILOG Investigators
Jul 22, 1998·Lancet·UNKNOWN EPISTENT Investigators
Mar 13, 1999·Annals of Internal Medicine·A S LeveyD Roth
Jan 11, 2000·Circulation·M H RubensteinI F Palacios
Mar 7, 2001·The American Journal of Cardiology·H H TingD R Holmes
Mar 29, 2001·The American Journal of Cardiology·M H RubensteinI F Palacios
Oct 5, 2001·Journal of the American College of Cardiology·A Al-AhmadM J Sarnak
Jan 17, 2002·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Luis GrubergMartin B Leon
Mar 30, 2002·Journal of the American College of Cardiology·Patricia J M BestPeter B Berger
Jun 1, 2002·Journal of the American College of Cardiology·Tamara B HorwichJeff Borenstein
Jun 22, 2002·Archives of Internal Medicine·Brad C AstorJosef Coresh
Feb 15, 2003·The American Journal of Medicine·Mikhail KosiborodHarlan M Krumholz
May 20, 2003·Kidney International. Supplement·Carmine ZoccaliGiovanni Tripepi
Citations
Jul 27, 2006·International Urology and Nephrology·Donald S SilverbergDoron Schwartz
Nov 23, 2006·Current Diabetes Reports·Eberhard Ritz
Mar 24, 2007·The American Journal of Cardiology·Judith E Mitchell
May 29, 2007·The American Journal of Cardiology·Michele D VoeltzSteven V Manoukian
Jul 25, 2009·JACC. Cardiovascular Interventions·Michael ReedHitinder S Gurm
Nov 3, 2005·Nature Clinical Practice. Cardiovascular Medicine·Adrian IainaDov Wexler
May 23, 2009·Medicina clínica·A CasesS Collado
Sep 24, 2008·Seminars in Hematology·John W Adamson
Jan 12, 2008·International Journal of Cardiology·Shaheeda AhmedC Michael Gibson
Sep 5, 2006·Seminars in Nephrology·Donald S SilverbergDoron Schwartz
Mar 30, 2007·Journal of Interventional Cardiology·Jacek KowalczykZbigniew Kalarus
Oct 7, 2011·The American Journal of Cardiology·Hitinder S GurmUNKNOWN Global Registry of Acute Coronary Events (GRACE) Investigators
Jan 13, 2005·American Heart Journal·Hitinder S Gurm, Deepak L Bhatt
Nov 9, 2005·The American Journal of Cardiology·Harold L DauermanRobert J Goldberg
Jun 6, 2009·Journal of the American College of Cardiology·Fadi G HageAmi E Iskandrian
Aug 20, 2011·Journal of the American College of Cardiology·Hitinder S GurmUNKNOWN BMC2 (Blue Cross Blue Shield of Michigan Cardiovascular Consortium) Registry
Oct 14, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tomonori KimuraTerumasa Hayashi
Sep 8, 2005·The Annals of Pharmacotherapy·A Scott Mathis, James J Gugger
Apr 4, 2017·Journal of Interventional Cardiology·P Michael GrossmanHitinder S Gurm
Nov 22, 2005·Seminars in Nephrology·Donald S SilverbergDoron Schwartz
Mar 30, 2012·Circulation. Cardiovascular Interventions·Thomas PilgrimStephan Windecker
Jan 27, 2007·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Michail I PapafaklisLampros K Michalis
Mar 25, 2005·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Ritesh GuptaStephen G Ellis
Feb 19, 2008·Coronary Artery Disease·Anderson D da SilveiraCarisi A Polanczyk
Jan 1, 2010·Anesthesia and Analgesia·Colin F MackenzieA Gerson Greenburg
Feb 17, 2006·Current Opinion in Nephrology and Hypertension·Claudine JurkovitzWilliam M McClellan
Oct 20, 2018·Chinese Medical Journal·Ying-Qing FengJi-Yan Chen
Jun 25, 2005·European Heart Journal·Alex HobsonPaul R Kalra
Oct 8, 2018·Journal of Vascular Surgery·Ziad Al AdasTimothy J Nypaver