Double-Organ Bias in Published Randomized Controlled Trials of Glaucoma

Journal of Glaucoma
Fehim EsenMuhsin Eraslan

Abstract

Most of the statistical tests used in significance testing are based on the assumption that each data entry is independent from other entries, however, we observe that in many articles researchers include data from 2 eyes as independent variables while performing these statistical tests. The aim of this study was to formally survey the prevalence of the above-mentioned "double-organ bias" in randomized controlled trials (RCT) of glaucoma. We did a PubMed search with the terms "glaucoma" and limitations "Humans" and "Randomized Controlled Trials" in 15 highest-impact-factor ophthalmology journals between November 2002 and November 2012. We only included RCTs published as an original article, where the aim was treating glaucoma. Two independent observers (M.K. and A.S.E.) read through each article and classified the articles according to treatment modality (medical, laser, or surgical) and presence of double-organ bias. The PubMed search yielded 270 articles. A total of 130 articles qualified for the survey. Eighty-five of the RCTs were medical studies, 11 were laser studies, and 34 studies evaluated the outcome of a surgical procedure. In 17 of the 130 articles (13.1%), double-organ bias was found. Prevalence of the double-organ...Continue Reading

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Citations

Sep 27, 2018·Eye & Contact Lens·Veysel AykutHalit Oguz
Aug 29, 2018·The British Journal of Ophthalmology·Fehim EsenHaluk Kazokoğlu
Nov 6, 2018·Eye and Vision·António CamposRufino Silva
Jul 25, 2018·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·António CamposRufino Silva
Mar 19, 2021·Seminars in Ophthalmology·Alev Ozcelik KoseSuleyman Kugu
Dec 15, 2020·Journal of Cataract and Refractive Surgery·Selim Genç, Fehim Esen
Jul 6, 2021·European Journal of Ophthalmology·Elvan Kucukkomurcu, Tayfun Sahin
Nov 26, 2020·Ophthalmic Plastic and Reconstructive Surgery·Mehmet Serhat Mangan, Fehim Esen
Dec 28, 2021·European Journal of Ophthalmology·Efthymios KarmirisEvangelia Chalkiadaki

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