Double robust estimation for multiple unordered treatments and clustered observations: Evaluating drug-eluting coronary artery stents

Biometrics
Sherri Rose, Sharon-Lise T Normand

Abstract

Postmarket comparative effectiveness and safety analyses of therapeutic treatments typically involve large observational cohorts. We propose double robust machine learning estimation techniques for implantable medical device evaluations where there are more than two unordered treatments and patients are clustered in hospitals. This flexible approach also accommodates high-dimensional covariates drawn from clinical databases. The Massachusetts Data Analysis Center percutaneous coronary intervention cohort is used to assess the composite outcome of 10 drug-eluting stents among adults implanted with at least one drug-eluting stent in Massachusetts. We find remarkable discrimination between stents. A simulation study designed to mimic this coronary intervention cohort is also presented and produced similar results.

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Citations

May 27, 2020·Statistical Methods in Medical Research·Liangyuan HuJuan Wisnivesky
Apr 3, 2020·International Journal of Epidemiology·Sherri Rose
Sep 2, 2021·Statistical Methods in Medical Research·Samrachana AdhikariSherri Rose
Sep 18, 2021·Statistics in Medicine·Margherita SilanBruno Arpino

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