Double role of mannose-binding lectin in relation to carotid intima-media thickness in patients with rheumatoid arthritis

Molecular Immunology
Lone N TroelsenSøren Jacobsen

Abstract

Patients with rheumatoid arthritis (RA) have increased risk of atherosclerosis and cardiovascular disease (CVD) that cannot be explained by excess of traditional risk factors. Several studies indicate that mannose-binding lectin (MBL) may modify the development of atherosclerosis; both high and low serum levels of MBL are reported to be associated with CVD. Intima-media thickness of the common carotid artery (ccIMT) is a validated non-invasive anatomic measure of subclinical CVD. We examined the relation between ccIMT and MBL in 114 RA patients. In a cross-sectional study MBL2 genotypes and serum concentrations of MBL were assessed; ccIMT was determined by means of ultrasonography; traditional and RA related cardiovascular risk modifiers were measured. The median ccIMT was 0.67 mm. The investigated MBL2 genotypes were not significantly associated with ccIMT. Using a general linear model, ccIMT was not linearly associated with serum MBL but was highly associated with the quadratic term of serum MBL (MBL(2)) (P=0.001) reflecting a U-shaped relation. MBL(2) was also significantly associated with ccIMT in a multivariable analysis adjusting for traditional and RA related cardiovascular risk modifiers (P=0.025). In RA patients, a qua...Continue Reading

References

Mar 12, 2003·Circulation·Daniel H SolomonGary C Curhan
Aug 23, 2003·The Journal of Infectious Diseases·Christian SøborgPeter Garred
May 27, 2004·Diabetes Care·Tara M WallaceDavid R Matthews
Jul 16, 2004·The New England Journal of Medicine·Tommy ØhlenschlaegerSøren Jacobsen
Jan 6, 2006·Genes and Immunity·P GarredH O Madsen
Sep 5, 2006·Tissue Antigens·R M DommettM W Turner
Apr 10, 2009·Current Vascular Pharmacology·Frederick PalmArmin Grau
Apr 17, 2009·The Journal of Rheumatology·Carmen García-GómezXavier Pintó

❮ Previous
Next ❯

Citations

Apr 16, 2013·Immunologic Research·Jenny Amaya-AmayaJuan-Manuel Anaya
Nov 27, 2015·Molecular Immunology·Stefanie Epp BoschmannIara J de Messias-Reason
Dec 17, 2015·Cardiovascular Ultrasound·Baoge Qu, Tao Qu
Nov 22, 2013·Clinical and Experimental Immunology·D P Eisen, M Osthoff
Apr 19, 2015·Arthritis Research & Therapy·Giuseppe A RamirezAngelo A Manfredi
Sep 2, 2014·BioMed Research International·Jenny Amaya-AmayaAdriana Rojas-Villarraga
Jul 16, 2014·Molecular Immunology·E HertleM M J van Greevenbroek
Dec 8, 2015·Journal of Diabetes Research·Miklós KáplárGyörgy Paragh
Dec 17, 2016·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M A F QueirozA C R Vallinoto
Oct 18, 2011·The Journal of Rheumatology·Fernanda Leticia MartinyJosé Artur Bogo Chies
Mar 11, 2021·Pharmacological Reviews·Peter GarredTom E Mollnes

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.