Double-sided 3D printing on paper towards mass production of three-dimensional paper-based microfluidic analytical devices (3D-μPADs)

Lab on a Chip
Chanyong ParkSungsu Park

Abstract

Recently, much effort has been focused on developing three-dimensional, paper-based microfluidic analytical devices (3D-μPADs) targeting in vitro diagnostics. However, 3D-μPAD fabrication typically requires tedious assembly that hinders mass production. Here, we report on a fabrication method for 3D-μPADs made of plastics without the need for additional assembly. Both sides of the paper were printed via liquid resin photopolymerization using a digital light processing (DLP) printer. The sample reservoir and detection zones are located on the top of the 3D-μPADs, and three microchannels are located on the bottom. The detection limits for glucose, cholesterol, and triglyceride (TG) in phosphate-buffered saline (PBS) were 0.3 mM, 0.2 mM, and 0.3 mM, respectively. The detectable ranges of glucose, cholesterol, and TG in human serum were 5-11 mM, 2.6-6.7 mM, and 1-2.3 mM. These results suggest that our fabrication method is suitable to mass produce 3D-μPADs with relative ease using simple fabrication processes.

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Citations

Oct 8, 2019·The Analyst·Bingbing GaoBingfang He
Aug 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hosub LimJinkee Lee
Jul 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Siraprapa BoobphahomKwanwoo Shin
Apr 22, 2021·Lab on a Chip·Wen-Chin LeeLung-Ming Fu
Mar 6, 2019·Analytical Chemistry·Diana F Cedillo-AlcantarAlexander Revzin

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