Double-stranded DNA breaks and gene functions in recombination and meiosis

Cell Research
Wuxing Li, Hong Ma


Meiotic prophase I is a long and complex phase. Homologous recombination is an important process that occurs between homologous chromosomes during meiotic prophase I. Formation of chiasmata, which hold homologous chromosomes together until the metaphase I to anaphase I transition, is critical for proper chromosome segregation. Recent studies have suggested that the SPO11 proteins have conserved functions in a number of organisms in generating sites of double-stranded DNA breaks (DSBs) that are thought to be the starting points of homologous recombination. Processing of these sites of DSBs requires the function of RecA homologs, such as RAD51, DMC1, and others, as suggested by mutant studies; thus the failure to repair these meiotic DSBs results in abnormal chromosomal alternations, leading to disrupted meiosis. Recent discoveries on the functions of these RecA homologs have improved the understanding of the mechanisms underlying meiotic homologous recombination.


Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·A T Carpenter
Apr 1, 1989·Genome Génome / Conseil National De Recherches Canada·M Bojko
Jan 1, 1989·Genome Génome / Conseil National De Recherches Canada·C N GirouxH F Tiano
Nov 1, 1995·Genes & Development·B RockmillG S Roeder
Jul 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·R S TebbsL H Thompson
Jan 1, 1995·Advances in Biophysics·H OgawaA H Hagihara
Jun 1, 1994·The Journal of Cell Biology·J LoidlH Scherthan
Aug 11, 1993·Nucleic Acids Research·W E Raymond, N Kleckner
Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·T Tsuzuki MoritaT
Dec 27, 1996·The Journal of Biological Chemistry·H JiangT Kodadek
Mar 10, 1997·The Journal of Cell Biology·A V Smith, G S Roeder
Apr 1, 1996·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·T IkeyaT Ogawa
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·F Baudat, A Nicolas
Aug 20, 1997·Chromosoma·P B MoensB Spyropoulos
Jan 14, 1998·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·A ShinoharaD K Bishop
Jan 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·K OhtaT Shibata
Jan 27, 1998·Genomics·J S AlbalaG G Lennon
Mar 31, 1998·Molecular & General Genetics : MGG·M P DoutriauxC White
Aug 15, 1998·The Journal of Biological Chemistry·K M TrujilloP Sung
Aug 15, 1998·The Journal of Biological Chemistry·D K BishopA Shinohara


Jun 26, 2009·Genetica·Sarah M Bennett, Mohamed A F Noor
Nov 24, 2011·Nature Reviews. Molecular Cell Biology·Seychelle M VosJames M Berger
Apr 12, 2013·BMC Genomics·Sree V ChintapalliRanden L Patterson
Jul 29, 2006·BMC Molecular Biology·Aneesh P PanoliImran Siddiqi
Jun 27, 2006·Proceedings of the National Academy of Sciences of the United States of America·Zhenguo LinHong Ma
Jan 7, 2011·Journal of Nucleic Acids·Rajesh P RastogiRajeshwar P Sinha
Sep 28, 2014·Nucleic Acids Research·Florence CharlotFabien Nogué
May 21, 2014·The Plant Journal : for Cell and Molecular Biology·Mi Young Byun, Woo Taek Kim
Mar 26, 2013·The Plant Journal : for Cell and Molecular Biology·Olivier Da InesCharles I White
Apr 18, 2012·The Plant Journal : for Cell and Molecular Biology·Jianhui JiZhukuan Cheng
Sep 10, 2014·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Anthony Le CigneChristophe Thiriet
May 29, 2015·European Journal of Immunology·Jenny M Karo, Joseph C Sun
Feb 19, 2015·Frontiers in Plant Science·Zhigang WuQiong Luo
Sep 24, 2016·Reproduction in Domestic Animals = Zuchthygiene·B LiQ Li
Dec 23, 2011·Biology of Reproduction·Andrew J Watson
Jan 1, 2012·Biomolecules·Hui Ling Ko, Ee Chee Ren
Dec 28, 2018·The Plant Journal : for Cell and Molecular Biology·Yun RenShuangcheng Li
Oct 13, 2017·Frontiers in Plant Science·Peipei ZhangShihua Cheng
Aug 26, 2020·Journal of Experimental Botany·Ian FayosEmmanuel Guiderdoni
Dec 17, 2020·Zygote : the Biology of Gametes and Early Embryos·Tingting GaoXiaoyan Huang
Mar 7, 2012·Journal of Cell Science·Yi ShenZhukuan Cheng

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.

Related Papers

Journal of Experimental Botany
Anthony P CarylF Christopher H Franklin
BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
Kiersten A Henderson, Scott Keeney
Annual Review of Cell and Developmental Biology
Scott L Page, R Scott Hawley
© 2021 Meta ULC. All rights reserved