Double trisomy in spontaneous abortions

Human Genetics
K S Reddy

Abstract

Cytogenetic data on products of conception from spontaneous abortions studied over a 10-year period have been reviewed for double trisomies. A total of 3034 spontaneous abortions were karyotyped between 1986 and 1997. Twenty-two cases with double trisomy, one case with triple trisomy, and a case with a trisomy and monosomy were found. The tissues studied were mostly sac, villi, or placenta. The gestational age ranged from 6 to 11 weeks and the mean age was 8.2 +/- 1.7 (SD) weeks. The mean maternal age in years was 35.9 +/- 5.3. Of the twenty-two cases, four were mosaics. All but two of the cases involved autosomal aneuploidies. The double trisomies included chromosomes 2, 4, 5, 7, 8, 12, 13, 14, 15, 16, 17, 18, 20, 21, and 22. The chromosomes that were trisomic in more than one double trisomy case were numbers 16 (8 cases), 8 (5 cases), 15 (4 cases), 2, 13, and 21 (3 cases each), and 5, 7, 14, 18, 20, 22, and X (2 cases). The triple trisomy involved chromosomes 18, 21, and X. The monosomy and trisomy case was a mosaic, with a monosomy 21 in all cells and some cells also with a trisomy 5. The double trisomies cited for the first time in this study were 4/13, 5/16, 8/14, 8/15, 14/21, 15/20, and 7/12. The pooled mean maternal age ...Continue Reading

Citations

Oct 4, 2000·Prenatal Diagnosis·C P ChenW Wang
Feb 4, 2005·American Journal of Medical Genetics. Part a·Rossano Rossino, Anna Lisa Nucaro
Apr 30, 2013·Journal of Assisted Reproduction and Genetics·Elizabeth X WuSai Ma
Mar 31, 2004·Annales de génétique·Dimitrios IliopoulosNikolaos Voyiatzis
Aug 31, 1999·Clinical Genetics·K S Reddy
Feb 16, 2002·Clinical Genetics·S ArbuzovaI Sehmi
Apr 19, 2005·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Joshua MenashaNataline B Kardon
Jan 20, 2010·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Stuart A ScottLisa Edelmann
Feb 17, 2007·Clinical Obstetrics and Gynecology·Joe Leigh Simpson
Dec 26, 2013·Case Reports in Obstetrics and Gynecology·Cetin AydinHalime Sen Selim
May 17, 2013·Archives of Gynecology and Obstetrics·Andreas RoosSimone Heidemann
Jan 17, 2009·Journal of Genetics·Wahied Khawar BalwanSubash Gupta
Oct 1, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Vida ČulićJasminka Pavelić
Mar 2, 2005·Congenital Anomalies·Qing Ying LiShin-ichi Sonta
Jun 9, 2006·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Dimitar N AzmanovDraga I Toncheva
Feb 8, 2006·European Journal of Medical Genetics·Ian A GlassPhilip D Cotter
Mar 18, 2015·Journal of Assisted Reproduction and Genetics·Inmaculada Campos-GalindoCarmen Rubio
Jan 28, 2015·Journal of Human Reproductive Sciences·Shivakumar SubramaniyamSusan Mathew
Mar 25, 2009·Genetic Testing and Molecular Biomarkers·Ali Irfan GuzelDeniz Tastemir
Dec 31, 2009·Prenatal Diagnosis·Mark MicaleDaniel L Van Dyke
Apr 1, 2004·European Journal of Human Genetics : EJHG·Igor N LebedevSergey A Nazarenko
Oct 17, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Suzhen QuXiangdong Kong
Apr 21, 2005·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Victor DezeregaWaldo Sepulveda
Dec 20, 2005·Human Reproduction·Dan Diego-AlvarezIsabel Lorda-Sanchez
May 1, 2018·Case Reports in Pathology·Sujal I ShahJerzy Stanek
Dec 24, 2020·Genes·Sandra Garcia-HerreroJavier Garcia-Planells

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