Double versus single intensive phototherapy with LEDs in treatment of neonatal hyperbilirubinemia

Journal of Perinatology : Official Journal of the California Perinatal Association
Mette L DonneborgFinn Ebbesen

Abstract

We investigate whether double phototherapy reduces total serum bilirubin concentration faster than single light during intensive phototherapy with high levels of irradiance using light-emitting diodes. Eighty-three infants with gestational age ⩾33 weeks and uncomplicated hyperbilirubinemia were randomized to either double (n=41) or single phototherapy (n=42) for 24 h. The mean irradiance was 64.8 μW cm-2 nm-1 from above and 39 μW cm-2 nm-1 from below. The percentage decreases of total serum bilirubin after 12 h of double vs single phototherapy were (mean (95% confidence interval (CI))) 39% (37 to 42) vs 30% (27 to 32), respectively (P<0.001). After 24 h, the decreases were 58% (56 to 61) vs 47% (44 to 50), respectively (P<0.001). The results were still significant after adjustment for confounding. The only side effect was loose stools. Even with intensive phototherapy increasing spectral power by increasing the irradiated body surface area, the efficacy of phototherapy is improved.

References

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Citations

Mar 10, 2019·Pediatric Research·Lori W E van der SchoorHenkjan J Verkade
Aug 20, 2019·Journal of Perinatology : Official Journal of the California Perinatal Association·Thor Willy Ruud HansenVinod K Bhutani
Jun 10, 2019·BMC Pediatrics·Mahendra T A SampurnaChristian V Hulzebos
Jan 24, 2020·European Journal of Pediatrics·Muhammad Abdullah NizamNabeel Ali Bhangar
Sep 5, 2021·Medical Engineering & Physics·Douglas M ClarksonPrakash Satodia

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