Double-wave-vector diffusion-weighting experiments with multiple concatenations at long mixing times

Journal of Magnetic Resonance
Marco Lawrenz, Jürgen Finsterbusch

Abstract

MR sequences where two diffusion-weighting periods are applied successively in a single acquisition seem to be a promising tool for the investigation of tissue structure on a microscopic level such as the characterization of the compartment size or eccentricity measures of pores. However, the application of such double-wave-vector (DWV) experiments on whole-body MR systems is hampered by the long gradient pulses required that have been shown to reduce the signal modulation. In this work, it is demonstrated that involving multiple concatenations of the two diffusion-weighting periods can ameliorate this problem in experiments with long mixing times between the two wave vectors. The recently presented tensor equation is extended to multiple concatenations. As confirmed by Monte-Carlo simulations, this model shows a good approximation of the signals observed for typical whole-body gradient pulse durations and the derived anisotropy measures are obtained with good accuracy. Most importantly, the signal modulation is increased with multiple concatenations because shorter gradient pulses can be used to achieve the desired diffusion-weighting. Thus, the multiple concatenation approach may help to improve the applicability and reliabil...Continue Reading

References

Apr 3, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M E KomloshP J Basser
Apr 19, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Martin A Koch, Jürgen Finsterbusch
Apr 25, 2008·The Journal of Chemical Physics·Evren Ozarslan, Peter J Basser
Sep 9, 2008·Journal of Magnetic Resonance·Jürgen Finsterbusch, Martin A Koch
Feb 11, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T WeberP M Jakob
Mar 10, 2009·Journal of Magnetic Resonance·Jürgen Finsterbusch
Mar 26, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Martin A Koch, Jürgen Finsterbusch

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Citations

Jan 29, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Marco Lawrenz, Jürgen Finsterbusch
Apr 14, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Marco Lawrenz, Jürgen Finsterbusch
May 23, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jonathan D ClaydenChris A Clark
Feb 26, 2019·Human Brain Mapping·Björn LampinenMarkus Nilsson
Jan 10, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Lawrence R FrankVitaly L Galinsky

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