Doublecortin-expressing cell types in temporal lobe epilepsy.

Acta Neuropathologica Communications
J Y W LiuM Thom

Abstract

Doublecortin (DCX) is widely regarded as a marker of immature and migrating neurons during development. While DCX expression persists in adults, particularly in the temporal lobe and neurogenic regions, it is unknown how seizures influence its expression. The aim of the present study was to explore the distribution and characteristics of DCX-expressing cells in surgical and postmortem samples from 40 adult and paediatric patients, with epilepsy and with or without hippocampal sclerosis (HS), compared to post mortem controls. The hippocampus (pes and body), parahippocampal gyrus, amygdala, temporal pole and temporal cortex were examined with DCX immunohistochemistry using four commercially-available DCX antibodies, labelled cells were quantified in different regions of interest as well as their co-expression with cell type specific markers (CD68, Iba1, GFAP, GFAP∂, nestin, SOX2, CD34, OLIG2, PDGFRβ, NeuN) and cell cycle marker (MCM2). Histological findings were compared with clinical data, as well as gene expression data obtained from the temporal cortex of 83 temporal lobe epilepsy cases with HS. DCX immunohistochemistry identified immature (Nestin-/NeuN-) neurons in layer II of the temporal neocortex in patients with and witho...Continue Reading

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Citations

May 6, 2019·The Journal of Comparative Neurology·Justin K EllisDavid H Rowitch
Jan 22, 2020·Neural Regeneration Research·Ruo-Xu LiuShao-Jun Liu
Aug 28, 2020·Nature Communications·Xinyu Zhao, Henriette van Praag
Jun 3, 2021·International Journal of Molecular Sciences·Jae-Yeon Kim, Mercedes F Paredes
Aug 28, 2021·Scientific Reports·Esther PototskiyAlberto E Musto

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Datasets Mentioned

BETA
GSE25219
GSE46706

Methods Mentioned

BETA
surgical resections
PCR

Software Mentioned

Affymetrix Power Tools
Zen 2012 blue lite
Image pro plus
Partek Genomics Suite
SPSS

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