Doublesex and mab-3 related transcription factor 1 (DMRT1) is a sex-specific genetic determinant of childhood-onset asthma and is expressed in testis and macrophages.

The Journal of Allergy and Clinical Immunology
Maximilian SchieckM Kabesch

Abstract

Asthma is a disease affecting more boys than girls in childhood and more women than men in adulthood. The mechanisms behind these sex-specific differences are not yet understood. We analyzed whether and how genetic factors contribute to sex-specific predisposition to childhood-onset asthma. Interactions between sex and polymorphisms on childhood asthma risk were evaluated in the Multicentre Asthma Genetics in Childhood Study (MAGICS)/Phase II International Study of Asthma and Allergies in Childhood (ISAAC II) population on a genome-wide level, and findings were validated in independent populations. Genetic fine mapping of sex-specific asthma association signals was performed, and putatively causal polymorphisms were characterized in vitro by using electrophoretic mobility shift and luciferase activity assays. Gene and protein expression of the identified gene doublesex and mab-3 related transcription factor 1 (DMRT1) were measured in different human tissues by using quantitative real-time PCR and immunohistochemistry. Polymorphisms in the testis-associated gene DMRT1 displayed interactions with sex on asthma status in a population of primarily clinically defined asthmatic children and nonasthmatic control subjects (lowest P = 5...Continue Reading

References

Mar 7, 1998·Nature·C S RaymondD Zarkower
Oct 10, 2003·The New England Journal of Medicine·Malcolm R SearsRichie Poulton
Dec 20, 2003·Nature·UNKNOWN International HapMap Consortium
Jan 1, 2004·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Michael Schatz, Carlos A Camargo
Mar 30, 2004·BMC Bioinformatics·Alberto Riva, Isaac S Kohane
Jun 25, 2004·Nucleic Acids Research·Kelly A FrazerInna Dubchak
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Nov 27, 2004·Journal of Cell Science·Jochen HessMarina Schorpp-Kistner
Apr 5, 2005·American Journal of Respiratory and Critical Care Medicine·Piush J MandhaneMalcolm R Sears
Apr 27, 2007·Biochimica Et Biophysica Acta·Ming YingRongjia Zhou
Nov 29, 2008·The Journal of Allergy and Clinical Immunology·Kathrin SuttnerMichael Kabesch
May 7, 2009·European Journal of Human Genetics : EJHG·Michela BarbaroAnna Wedell
May 16, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Satish L DeshmaneBassel E Sawaya
Apr 1, 2010·Nature Methods·Ivan A AdzhubeiShamil R Sunyaev
Jun 15, 2010·Nature Genetics·Clare TurnbullUNKNOWN UK Testicular Cancer Collaboration
Oct 29, 2010·Nature·UNKNOWN 1000 Genomes Project ConsortiumGil A McVean
Nov 26, 2010·PloS One·Sven MichelMichael Kabesch
May 31, 2011·Developmental Biology·Anthony D KrentzDavid Zarkower
Jul 22, 2011·Nature·Clinton K MatsonDavid Zarkower
Jan 14, 2012·Endocrine Reviews·Elizabeth A TownsendY S Prakash
Feb 9, 2012·Nature Reviews. Genetics·Clinton K Matson, David Zarkower
Aug 23, 2012·Mucosal Immunology·J Balhara, A S Gounni
Apr 16, 2014·Mediators of Inflammation·Ankita Aggarwal, Devendra K Agrawal
May 6, 2014·The Lancet. Respiratory Medicine·Deborah A MeyersStephen T Holgate
May 16, 2014·Human Molecular Genetics·Rachel A MyersUNKNOWN GRAAD
Aug 30, 2014·American Journal of Respiratory and Critical Care Medicine·Jon Genuneit
Apr 14, 2015·The Journal of Allergy and Clinical Immunology·Heidi SchaarschmidtStephan Weidinger

❮ Previous
Next ❯

Citations

Jul 28, 2016·Pulmonary Pharmacology & Therapeutics·Ibrahim SulaimanJohnson Stanslas
Dec 5, 2016·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·Anu Bashamboo, Ken McElreavey
May 1, 2017·International Archives of Allergy and Immunology·Mariona PinartThomas Keil
Mar 23, 2017·Epigenomics·Daniel P PotaczekJörg Tost
Jul 11, 2018·Frontiers in Pediatrics·Giuliana Ferrante, Stefania La Grutta
Feb 26, 2019·Frontiers in Pediatrics·Natalia Hernandez-PachecoCarlos Flores
Dec 2, 2017·European Journal of Medical Genetics·Fang Kong, Donna M Martin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.