Down-expression pattern of Ku70 and p53 coexisted in colorectal cancer

Medical Oncology
Yuanfang LuYuanming Lu

Abstract

To address the relationship of altered expression of double-strand break repair proteins Ku70 and p53 in clinical colorectal cancer (CRC), we examined the expression pattern of Ku70 and p53 by using fluorescent immunohistochemistry and real-time PCR assays in CRC and pericancerous samples from 152 Chinese patients. The results showed that down-expression pattern of both Ku70 and p53 coexisted in the CRC samples with significant correlating rate (R (2) = 0.9103; P < 0.001), and the down-expression of Ku70 and p53 was significantly associated with the advanced tumor node metastasis stage (Ku70: HR 3.453 in recurrence and 4.182 in survival, P < 0.001; P53: HR 3.114 in recurrence and 4.113 in survival, P < 0.001). The down-regulated Ku70 and p53 were associated with poor disease-free survival. Loss of Ku70 and p53 expression might serve as a biomarker of poor prognosis in CRC patients.

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Citations

Jan 25, 2017·Biochemical and Biophysical Research Communications·Shihao XiangJiali Ma
Feb 6, 2017·Biochemical and Biophysical Research Communications·Jiali MaShihao Xiang
Jul 11, 2018·The American Journal of Chinese Medicine·Sumei WangWanyin Wu
Apr 30, 2017·Experimental & Molecular Medicine·Kwangbeom HyunJaehoon Kim

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