Down-regulated expression of A disintegrin and metalloproteinase with thrombospondin-like repeats-1 by progesterone receptor antagonist is associated with impaired expansion of porcine cumulus-oocyte complexes

Endocrinology
Masayuki ShimadaJ S Richards

Abstract

ADAMTS-1, a member of the A disintegrin and metalloproteinase family of proteases, is expressed in rodent follicles via progesterone receptor (PR)-dependent pathways. However, the functional relationship between ADAMTS-1 expression and PR has not been studied extensively in other species. In the present study, we investigated the time-dependent changes in ADAMTS-1 expression in cumulus cells of porcine cumulus-oocyte complexes (COCs), and the roles of ADAMTS-1 in cumulus expansion during in vitro maturation of oocytes. ADAMTS-1 message was not detected in cumulus cells at the time of collection from the follicles. In response to gonadotropins, ADAMTS-1 mRNA was dramatically up-regulated and reached a maximum at 20 h. The level of mature ADAMTS-1 protein increased in a time-dependent manner with a maximum level at 40 h. The induction of ADAMTS-1 mRNA and protein was significantly decreased by the addition of PR antagonist RU486 to the cultures. However, RU486 did not affect the expression of ADAMTS-4 or factors that had been reported to be required for COC expansion (TSG-6, versican, HA synthase-2). COCs cultured with FSH and LH for 40 h exhibited prominent cumulus expansion. The expansion was reduced significantly by the additi...Continue Reading

References

Aug 1, 1979·Biology of Reproduction·N Dekel, D M Phillips
Apr 1, 1977·The Journal of Endocrinology·T MoriA Kambegawa
Feb 1, 1992·Matrix : Collagen and Related Research·C N BertolamiD V Messadi
May 1, 1989·Journal of Steroid Biochemistry·M BeatoE P Slater
Jul 1, 1984·Proceedings of the Society for Experimental Biology and Medicine·B W SnyderH P Schane
Sep 15, 1995·Genes & Development·J P LydonB W O'Malley
Dec 1, 1994·Endocrine Reviews·J S Richards
Jun 22, 1999·The Journal of Biological Chemistry·K KunoK Matsushima
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·R L RobkerJ S Richards
Aug 17, 2000·The Journal of Biological Chemistry·J C Rodriguez-ManzanequeM L Iruela-Arispe
Oct 4, 2002·Reproduction : the Official Journal of the Society for the Study of Fertility·M ShimadaT Terada
Feb 15, 2003·Endocrinology·Darryl L RussellJoanne S Richards
Aug 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Biserka Mulac-JericevicOrla M Conneely
Aug 9, 2003·The Journal of Biological Chemistry·Darryl L RussellJoAnne S Richards
Nov 8, 2003·Molecular and Cellular Endocrinology·Tetsuji OkazakiMasayuki Shimada
Dec 12, 2003·Biology of Reproduction·L MittazM A Pritchard
Jan 31, 2004·Biochemical and Biophysical Research Communications·Norio ItoShigehiko Mizutani

❮ Previous
Next ❯

Citations

Sep 12, 2007·Journal of Assisted Reproduction and Genetics·Junichi HasegawaTakashi Okai
Mar 27, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Sergio Romero, Johan Smitz
Oct 20, 2012·Reproduction : the Official Journal of the Society for the Study of Fertility·J BeekA Van Soom
Sep 24, 2005·Proceedings of the National Academy of Sciences of the United States of America·Susanne TranguchSudhansu K Dey
Jul 27, 2010·Molecular and Cellular Endocrinology·Yuval YungAriel Hourvitz
Jan 9, 2007·Reproductive Biomedicine Online·Chikako SatoTakafumi Utsunomiya
Aug 1, 2012·Reproduction in Domestic Animals = Zuchthygiene·T Fair, P Lonergan
Aug 26, 2014·Molecular and Cellular Endocrinology·Derek TomsJulang Li
Mar 31, 2015·Matrix Biology : Journal of the International Society for Matrix Biology·Darryl L RussellKylie R Dunning
Oct 21, 2016·The Journal of Reproduction and Development·Ruth AppeltantKazuhiro Kikuchi
Jan 19, 2018·International Journal of Molecular Sciences·Eva Nagyova
Jan 21, 2010·Nuclear Receptor Signaling·Rebecca L RobkerDarryl L Russell
Mar 29, 2020·International Journal of Molecular Sciences·Eva NagyovaAntonella Camaioni
May 12, 2012·Reproductive Medicine and Biology·Masayuki Shimada
Jan 30, 2015·American Journal of Physiology. Endocrinology and Metabolism·Bo PanJulang Li
Feb 15, 2016·Reproductive Medicine and Biology·Masayuki ShimadaYumi Hoshino
Feb 11, 2021·Reproduction in Domestic Animals = Zuchthygiene·Juliana de Carvalho DelgadoMayra Elena Ortiz D'Ávila Assumpção
Apr 24, 2021·Zygote : the Biology of Gametes and Early Embryos·Eryk AndreasDawit Tesfaye
Nov 22, 2007·Reproductive Biomedicine Online·Kimihisa TajimaFumikazu Kotsuji

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.