Abstract
Our previous studies have shown that decreased expression of Annexin A7 elevates apoptosis in Hca-P cells, a hepatocarcinoma cell line with lymphatic metastatic potential. In this study, RNA interference technique was used to down-regulate the expression of Annexin A7, and unmanipulated Hca-P cells and transfected nonspecific-sequence Hca-P cells as control. The down-regulation of Annexin A7 declined the cell viability after cisplatin exposure. And the reduced expression of Annexin A7 decreased the expression of Bcl2, increased the expression of Cytochrome-C in the cytoplasme, and then improved the expression of Caspase-3. However there was no significant effect on the expression of Bax, Caspase-12, Fas, FasL and Caspase-8. The results indicate that the decreased expression of Annexin A7 could inhibit the proliferation, and increase the apoptosis of Hca-P cells by affecting the expression of the apoptosis associated proteins by the mitochondrial pathway.
References
Aug 14, 1992·Biochemical and Biophysical Research Communications·H TokumitsuH Hidaka
Apr 5, 1994·Biochimica Et Biophysica Acta·P Raynal, H B Pollard
Jan 9, 1999·The Journal of Biological Chemistry·P VitoL D'Adamio
Mar 10, 2001·Cell·R M LocksleyM J Lenardo
Jun 2, 2001·The EMBO Journal·P PintonR Rizzuto
Feb 13, 2002·The Journal of Biological Chemistry·Fei YuHyeong-Reh Choi Kim
Mar 28, 2002·Physiological Reviews·Volker Gerke, Stephen E Moss
Nov 26, 2002·Biochimica Et Biophysica Acta·Hirokazu SatohMasatoshi Maki
Dec 25, 2002·Cancer Cell·Rachel E PalmerDaniel A Haber
Mar 17, 2005·World Journal of Gastroenterology : WJG·Bo SongLei Sun
Jun 2, 2005·Nature Reviews. Molecular Cell Biology·Volker GerkeStephen E Moss
Aug 14, 2008·The Journal of Pathology·S Mussunoor, G I Murray
Dec 15, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Raquel T LimaM Helena Vasconcelos
Sep 29, 2011·Journal of Experimental & Clinical Cancer Research : CR·Rebecca S Y Wong
Apr 2, 2013·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yan-Ling JinJian-Wu Tang
Jan 1, 2014·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lin SongJian-Wu Tang
Feb 18, 2014·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xianyan WangJianwu Tang
Jul 30, 2014·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yuhong HuangJianwu Tang
Citations
Aug 11, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xian-Yan WangJian-Wu Tang
Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lulu BaiJianwu Tang
Dec 6, 2016·Journal of Applied Toxicology : JAT·Ngoc Q VuongPremkumari Kumarathasan
Jun 13, 2018·Journal of Cellular Biochemistry·Yuanli HuangYuanrong Yang
Aug 26, 2019·American Journal of Reproductive Immunology : AJRI·Hui-Qin MoYan Zhang
Feb 26, 2016·Oncotarget·Shuqing LiuMing-Zhong Sun
Oct 24, 2018·Cancer Biomarkers : Section a of Disease Markers·Yina ZhaoXin Li
Aug 11, 2020·BioMed Research International·Qi DengYanling Jin