Down-regulation but not phosphorylation of stathmin is associated with induction of HL60 cell growth arrest and differentiation by physiological agents

FEBS Letters
W E JohnsonG Brown

Abstract

Stathmin is a cytosolic phosphoprotein that has an important but, as yet, undefined role in cell proliferation and differentiation. Induction of growth arrest and differentiation of HL60 cells to monocytes by phorbol 12-myristate 13-acetate is associated with rapid phosphorylation of the protein. Stathmin phosphorylation was not seen when HL60 cells were induced to differentiate to monocytes, by 1 alpha, 25-dihydroxyvitamin D3, and to neutrophils, by all-trans retinoic acid and granulocyte colony stimulating factor. In all the above instances, stathmin expression was down-regulated. Thus, increased stathmin phosphorylation is not required for cell growth arrest or differentiation or down-regulation of stathmin expression.

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Citations

Jun 27, 2000·Leukemia Research·R A SteinmanD S Shields
Mar 10, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·S R FlorellS A Leachman
Jan 26, 2006·American Journal of Physiology. Renal Physiology·Kamyar ZahediManoocher Soleimani
Mar 29, 2014·BMB Reports·Joao Agostinho Machado-NetoFabiola Traina
Jun 14, 1996·The Journal of Biological Chemistry·U K SchubartW Edelmann
Oct 2, 2009·Journal of Proteome Research·Wei-Qiang ChenGert Lubec

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