Down-regulation of ASY/Nogo transcription associated with progression of adult T-cell leukemia/lymphoma

International Journal of Cancer. Journal International Du Cancer
Misuzu ShimakageMasuo Yutsudo

Abstract

Adult T-cell leukemia/lymphoma (ATLL) is an aggressive form of human leukemia/lymphoma. Although this disease is initiated by infection with human T-lymphotropic virus type 1 (HTLV-1), many HTLV-1 carriers survive for a long period without aggressive illness, suggesting that other factors may play roles in the progression of ATLL to an aggressive state. However, the mechanism involved in this progression still remains unclear. Previously, we have reported that ASY/Nogo mRNA was markedly down-regulated in human small-cell lung carcinomas, whereas it was expressed in normal tissues and other lung carcinomas, such as adenocarcinoma and squamous cell carcinoma. To understand whether or not ASY/Nogo gene is involved in the progression of ATLL, we examined the expression of ASY/Nogo mRNA in smoldering, chronic and aggressive ATLL, and found that the expression level of ASY/Nogo mRNA was markedly reduced in clinically aggressive ATLL. HTLV-1 Tax expression was not affected by the down-regulation of ASY/Nogo mRNA. These results indicate that the ASY/Nogo gene may act as a suppressor against ATLL progression, independent of Tax expression.

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Citations

Mar 13, 2013·Pathology Oncology Research : POR·Kui ZhangLin Zhang
Sep 11, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Angelika B KritzAndrew H Baker
Feb 23, 2013·DNA and Cell Biology·Yang LiAkihiro Watari
Jan 6, 2007·International Journal of Cancer. Journal International Du Cancer·Daisuke NagakuboOsamu Yoshie
Jun 13, 2017·Frontiers in Oncology·Maria Sol Herrera-Cruz, Thomas Simmen

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