Abstract
The beta3-adrenergic receptor (beta3-AR) exerts a central role in the transduction of catecholamine effects in white and brown adipose tissue (WAT and BAT). A recent report has documented that insulin strongly down-regulates beta3-AR expression and catecholamine responsiveness in 3T3-F442A adipocytes [Fève, El Hadri, Quignard-Boulangé and Pairault (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 5677-5681]. In the present report we show that the rise in plasma insulin levels elicited by the fasted/fed transition is associated with a reduction in beta3-AR mRNA levels and beta-adrenergic responsiveness in WAT and BAT. beta3-AR transcripts are also decreased in adipose tissue from animals subjected for 6 h to euglycaemic hyperinsulinaemic glucose clamps. Moreover, insulin acts directly on cultured rat white and brown adipocytes to decrease beta3-AR gene expression and adenylate cyclase activity in response to beta3-AR-selective agonists. These results suggest that there is a close relationship between food intake, plasma insulin levels and beta3-AR expression.
Citations
Aug 13, 1999·The American Journal of Physiology·M Desautels, S Heal
Dec 26, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·G MoryR Bazin
Apr 18, 2003·American Journal of Physiology. Endocrinology and Metabolism·M P RamosE Herrera
Dec 3, 2004·The Journal of Pharmacology and Experimental Therapeutics·Dana S HutchinsonRoger J Summers
Dec 6, 2005·Cell and Tissue Research·Esperanza PujolIsabel Lladó
Jan 4, 2013·PloS One·Siva Sankara Vara Prasad SakamuriVajreswari Ayyalasomayajula
Jun 16, 2005·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Margalida FronteraMagdalena Gianotti
Feb 8, 2008·Bulletin of Experimental Biology and Medicine·A O ShpakovM N Pertseva
Dec 5, 2015·Frontiers in Endocrinology·Yoshiyuki KasaharaKatsuhiko Nishimori
Jan 6, 2017·Cell Death & Disease·Liping JuWeiping Jia
Nov 23, 2005·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Esperanza PujolPilar Roca
Nov 12, 2003·Experimental Biology and Medicine·Yin LiYasushi Saito
Mar 22, 2000·British Journal of Pharmacology·D S HutchinsonR J Summers
May 12, 2016·Basic Research in Cardiology·Adrien KleindienstCyril Reboul
Mar 14, 2000·Archives of Medical Research·E García-Rubi, J Calles-Escandón
Aug 2, 2003·Biochemical and Biophysical Research Communications·Fabrice BertileThierry Raclot
Apr 15, 2004·Archives of Biochemistry and Biophysics·Jiro NakamuraYasushi Kawakami
May 22, 2007·Metabolism: Clinical and Experimental·Naoki HarikaiAtsushi Ichikawa
Aug 19, 2007·Metabolism: Clinical and Experimental·Takuya SakuraiTetsuya Izawa