Down-regulation of CEACAM1 in breast cancer

Acta Biochimica Et Biophysica Sinica
Changcheng YangFeng Gao

Abstract

Carcinoembryonic antigen-related adhesion molecule 1 (CEACAM1) is a type 1 transmembrane glycoprotein belonging to the CEA family, which has been found to exist as either soluble forms in body fluids or membrane-bound forms on the cell surface. Aberrant CEACAM1 expression is associated with tumor progression and has been found in a variety of human malignancies. Increasing interest has been devoted to the expression of CEACAM1 in breast cancer, but most of these findings are contradictory. The aim of this study was to investigate CEACAM1 expression in breast cancer in greater detail. Using immunohistochemical staining, we found that CEACAM1 expression was reduced or lost in breast cancer tissues compared with noncancerous breast tissues. In addition, soluble CEACAM1 levels in the culture medium of breast cancer cell lines were significantly lower than those in a nontumorigenic breast epithelial cell line. Immunofluorescence analysis consistently showed that breast cancer cell lines have relatively low expression of membrane-bound CEACAM1. Furthermore, CEACAM1 mRNA and protein expression levels were down-regulated in breast cancer cell lines as measured using real-time reverse transcriptase-polymerase chain reaction and western ...Continue Reading

References

Jan 1, 1996·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·F PrallC Wagener
Feb 20, 1997·International Journal of Cancer. Journal International Du Cancer·K TanakaK Imai
Jul 1, 1997·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L RiethdorfT Löning
Aug 15, 2001·Experimental Cell Research·N BeaucheminW Zimmermann
Oct 12, 2004·The Journal of Pathology·Robert KammererWolfgang Zimmermann
May 26, 2006·Nature Reviews. Immunology·Scott D Gray-Owen, Richard S Blumberg
Dec 5, 2006·International Journal of Colorectal Disease·Wan-Yi KangChee-Yin Chai
Apr 21, 2007·Pancreas·Diane M SimeoneCraig D Logsdon
Jan 25, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Sebastian DangoBernward Passlick
May 23, 2009·American Journal of Clinical Pathology·Thilo GambichlerAlexander Kreuter
Jul 28, 2009·Cancer Immunology, Immunotherapy : CII·Gal MarkelJacob Schachter
Jun 5, 2010·Pathology Oncology Research : POR·Jae Hwi SongWon Sang Park
Jul 4, 2012·Annali Dell'Istituto Superiore Di Sanità·Valentina FioriMaurizio Cianfriglia
Aug 2, 2013·Cancer Metastasis Reviews·Nicole Beauchemin, Azadeh Arabzadeh
Jun 11, 2014·World Journal of Gastroenterology : WJG·Hong MuXiao-Hang Zhao

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Citations

Jul 29, 2016·Medical Molecular Morphology·Fu-Fang WangCheng-Jun Zhou
Oct 4, 2016·Histochemistry and Cell Biology·Uwe RueckschlossSüleyman Ergün
Jul 10, 2018·RNA Biology·Joice De Faria Poloni, Diego Bonatto
Mar 10, 2020·International Journal of Cancer. Journal International Du Cancer·Andreas M LuebkeJan Meiners
Nov 1, 2017·Oncology Letters·Changcheng YangFeng Gao
Jan 9, 2021·British Journal of Cancer·Sunil S BadveFiona Ginty
Feb 7, 2020·Biochemistry and Biophysics Reports·Soichiro HayashiSiro Simizu
Nov 1, 2018·ACS Applied Materials & Interfaces·Shengwang ZhouMilan Mrksich

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