Down-regulation of dendritic cell activation induced by Paracoccidioides brasiliensis

Immunology Letters
Karen Spadari FerreiraSandro Rogério Almeida

Abstract

Paracoccidioidomycosis (PCM) endemic in Latin America, is a progressive systemic mycosis caused by Paracoccidioides brasiliensis (Pb). The infection can evolve to different clinical forms that are associated to various degrees of suppressed cell-mediated immunity. With the recognition that DCs are able to initiate response in naïve T cells and that they also participate in Th cell education, the present study was undertaken to check whether DCs interact with P. brasiliensis, as well as to elucidate possible mechanisms and consequences of this interaction. Our results indicate that P. brasiliensis infection and purified gp43, its main antigenic component, lead to down-regulation of MHC-II and adhesion properties of immature DCs. The down-regulation was also observed in LPS-induced DC maturation. In addition, an inhibition of IL-12 and TNF-alpha production by both P. brasileinsis or gp43, was observed in LPS-induced DC maturation. These results suggest that protein, released in great amounts by the fungus, might be used, to reduce the effectiveness of the immune response.

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Citations

Jul 9, 2008·Medical Mycology·John S ReifGregory D Bossart
Jan 12, 2012·PLoS Neglected Tropical Diseases·Aldo H TavaresIldinete Silva-Pereira
Apr 10, 2013·Medical Mycology·Aline Raquel VoltanMaria José Soares Mendes-Giannini
May 2, 2015·Virulence·Sharanjeet K ThindJoshua D Nosanchuk
Nov 19, 2019·Frontiers in Microbiology·Ana Camila Oliveira SouzaAnamelia Lorenzetti Bocca
Sep 9, 2008·Mycopathologia·Vera Lúcia Garcia CalichAdriana Pina
Mar 9, 2021·Frontiers in Cellular and Infection Microbiology·Gustavo Giusiano

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