Down-regulation of ETS2 inhibits the invasion and metastasis of renal cell carcinoma cells by inducing EMT via the PI3K/Akt signaling pathway

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Guang-Wei ZhangChao-Yang Zhu

Abstract

V-ets erythroblastosis virus E26 oncogene homolog 2 (ETS2), belonging to the ETS family of transcription factors, is implicated in a broad range of cellular functions. Recently, ETS2 has been found playing an important role in the progression of some types of cancers. However, it remains unclear whether ETS2 has any effects on renal cell carcinoma (RCC). In this study, we investigated the biological functions of ETS2 in RCC. The results showed that ETS2 was highly expressed in RCC tissues and cell lines and its expression had an association with clinicopathological characteristics of RCC patients. In addition, down-regulation of ETS2 significantly inhibited RCC cell invasion in vitro and metastasis in vivo as well as suppressed the epithelial-mesenchymal transition (EMT) process. We also found that ETS2 down-regulation significantly reduced the levels of PI3K and Akt phosphorylation in RCC cells. Taken together, we suggest that ETS2 is of potential value as a molecular target for RCC treatment.

References

May 7, 1998·The International Journal of Biochemistry & Cell Biology·A D SharrocksP R Yates
Apr 28, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R J MotzerE M Metz
Feb 15, 2001·Oncogene·J S Yordy, R C Muise-Helmericks
Feb 15, 2001·Oncogene·G Mavrothalassitis, J Ghysdael
Jan 18, 2003·World Journal of Gastroenterology : WJG·Xin LiZhi-Hua Liu
Jul 10, 2003·Critical Reviews in Oncology/hematology·Robert J Motzer
Aug 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James C YangSteven A Rosenberg
Mar 23, 2004·Journal of Cellular Biochemistry·Tien HsuDennis K Watson
Mar 25, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eddie MyersLeonie S Young
Apr 7, 2005·World Journal of Urology·John S LamRobert A Figlin
Oct 11, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Arun Seth, Dennis K Watson
Dec 29, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Y BuggyM J Duffy
Mar 28, 2007·Trends in Endocrinology and Metabolism : TEM·Arthur Gutierrez-HartmannAndrew P Bradford
Mar 4, 2008·Cancer Treatment Reviews·Kiran GuptaClaudie Charbonneau
Apr 15, 2008·Trends in Molecular Medicine·Nancy Gavert, Avri Ben-Ze'ev
Jul 1, 2008·The Journal of Biological Chemistry·Dakang XuJun-Ping Liu
May 8, 2010·Nature Reviews. Urology·Wong-Ho ChowSusan S Devesa
Jun 3, 2010·The EMBO Journal·Gong-Hong WeiJussi Taipale
May 10, 2011·Annual Review of Biochemistry·Peter C HollenhorstBarbara J Graves
Jan 11, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Laurence AlbigesBernard Escudier
Feb 3, 2012·Carcinogenesis·Yu-Lun LiaoWen-Chang Lin
May 11, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mohamed KabboutHumam Kadara

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Citations

Oct 24, 2019·Laboratory Investigation; a Journal of Technical Methods and Pathology·Fang YaoXiaochun Bai
Sep 5, 2019·Asian-Australasian Journal of Animal Sciences·Dongjiao NiXinhua Zou
Apr 26, 2020·Molecular Biology Reports·Ningni JiangJuan Peng
Jun 8, 2019·Molecular Medicine Reports·Peng HaoFeihong Ma

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