Down-regulation of glomerular matrix metalloproteinase-2 gene in human NIDDM

Diabetologia
D Del PreteG Gambaro

Abstract

Regulation of mesangial matrix deposition is a dynamic phenomenon involving synthetic and degradative processes. The latter involve a number of matrix metalloproteinases (MMP) and tissue inhibitors of matrix metalloproteinases (TIMP). Experimental studies suggest that mesangial matrix degradation is inhibited in diabetic nephropathy, and that this phenomenon has a pathogenic role. The expression of genes for MMP2 and TIMP2 in human diabetic nephropathy was investigated. Reverse transcription polymerase chain reaction was carried out in microdissected glomeruli and tubulo-interstitium obtained from kidney biopsies. We studied 16 NIDDM patients, 5 patients with glomerulonephritis or chronic kidney transplant rejection, and 5 normal control subjects. Albumin excretion rate and renal histology for NIDDM patients were available. Contrary to TIMP2 which was expressed both in tubulo-interstitium and glomeruli in almost all renal biopsies, MMP2 gene down-regulation was observed in glomeruli from all NIDDM patients, irrespective of the albumin excretion rate, and of renal histology. In contrast, this gene was expressed in biopsies from other subjects (chi(2) = 20.6; p = 0.000). In conclusion, this study demonstrates that: 1) in glomerul...Continue Reading

Citations

Jan 18, 2012·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Junghyun KimJin Sook Kim
Jul 29, 2005·The American Journal of Pathology·Akari InadaYutaka Seino
Oct 27, 2001·Diabetic Medicine : a Journal of the British Diabetic Association·P R MaxwellD Gordon
Sep 21, 2000·Kidney International. Supplement·D J LeeheyR Singh
Mar 19, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kengo FuruichiTakashi Wada
Apr 14, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Cuixiang LiHanmin Wang
Oct 3, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Yoshimi TakamiyaSeiya Okuda
Apr 11, 2000·Current Opinion in Nephrology and Hypertension·S G AdlerM F Seldin
Jul 27, 2002·Annual Review of Genomics and Human Genetics·Jordan T Shin, Mark C Fishman
Jan 14, 2011·American Journal of Physiology. Renal Physiology·Jan M WilliamsRichard J Roman
Dec 6, 2001·The Journal of Clinical Investigation·F CornacchiaG E Striker
Jul 18, 2008·Journal of the American Society of Nephrology : JASN·Tri Q NguyenRoel Goldschmeding
May 12, 2007·The Review of Diabetic Studies : RDS·He-Lin DingZu-Zhi Fu
Aug 1, 2012·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Aimun K AhmedTimothy S Johnson
Aug 11, 2007·Bioscience, Biotechnology, and Biochemistry·Akari InadaAtsushi Fukatsu
Nov 13, 2004·Current Diabetes Reports·Daniela Hohenadel, Fokko J van der Woude
Aug 6, 2014·The International Journal of Biochemistry & Cell Biology·Louise Tzung-Harn HsiehLiliana Schaefer
May 25, 2007·Connective Tissue Research·Paul E NormanJonathan Golledge
Dec 9, 2008·Journal of Diabetes and Its Complications·Athanasia PapazafiropoulouNicholas Tentolouris
Mar 22, 2008·Translational Research : the Journal of Laboratory and Clinical Medicine·Horng-Rong ChangShu-Chen Chu
Apr 23, 2004·Journal of Clinical Laboratory Analysis·Kyoichi TashiroYasuhiko Tomino
Jul 29, 2006·The Journal of Pharmacy and Pharmacology·N Kamalakkannan, P Stanely Mainzen Prince
Jan 24, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·S JacqueminetJ-L Beaudeux
Nov 30, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Horng-Rong ChangJong-Da Lian
Feb 24, 2012·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Geum-Hwa LeeHyung-Ryong Kim
Mar 29, 2005·Angiology·Nikolaos P KadoglouChristos D Liapis
Jan 1, 2010·Journal of Dental Research·S RoyA Chronopoulos
Jun 8, 2018·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Nikesh DattaniMatthew J Bown
Sep 6, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Subrina JesminAkira Kitabatake
Aug 22, 2014·Diabetology & Metabolic Syndrome·Kei FukamiJosephine M Forbes
Feb 25, 2018·Molecular and Cellular Biochemistry·Raphael M SinghTehreem Waqar
Dec 28, 2006·American Journal of Physiology. Renal Physiology·J M CataniaA R Parrish
Mar 17, 2000·The Journal of Clinical Endocrinology and Metabolism·M ShinadaL A Bach
Nov 3, 2016·American Journal of Physiology. Renal Physiology·Caroline B Marshall
Feb 24, 2017·American Journal of Physiology. Renal Physiology·Wilhelm KrizHermann Josef Gröne
Sep 14, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Carla IacobiniGiuseppe Pugliese
Mar 16, 2001·American Journal of Physiology. Renal Physiology·J YaoT Oite

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