Down-regulation of hepatic lipase expression in experimental nephrotic syndrome

Kidney International
K Liang, Nosratola D Vaziri

Abstract

Hepatic lipase (HL) plays an important role in catabolism of chylomicron remnants, conversion of intermediate density lipoprotein (IDL) to low-density lipoprotein (LDL) and reverse transport of cholesterol to the liver. Several features of the nephrotic dyslipidemia point to the possible presence of HL deficiency. In an attempt to address this possibility, gene expression of HL was studied in rats with puromycin-induced nephrotic syndrome (NS). The results were compared with those obtained in a group of placebo-treated control animals. The NS group showed marked proteinuria, hypoalbuminemia, hypercholesterolemia, hypertriglyceridemia, normal creatinine clearance and normal hepatic tissue cholesterol concentration. HL activity of the liver tissue was reduced by approximately 60% in the NS group as compared to that found in the normal control group. The reduction of HL activity in the NS group was accompanied by a reduction of HL mRNA of virtually similar magnitude. HL activity of the liver tissue was inversely related to urinary protein excretion, serum cholesterol and serum triglyceride concentrations. In contrast, HL activity was directly related to serum albumin concentration and HL mRNA. No significant difference was observe...Continue Reading

References

Nov 14, 1978·Biochemical and Biophysical Research Communications·H JansenW C Hülsmann
Oct 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·U BeisiegelG Bengtsson-Olivecrona
Jan 16, 1990·Biochimica Et Biophysica Acta·F SultanS Griglio
Aug 30, 1990·The New England Journal of Medicine·J JovenM Vallés
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M C Komaromy, M C Schotz
May 1, 1987·Metabolism: Clinical and Experimental·I StapransW G Couser
Jan 1, 1986·Methods in Enzymology·C Ehnholm, T Kuusi
Nov 1, 1993·Kidney International·P StenvinkelA Alvestrand
Jan 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·F KronenbergH Dieplinger
May 15, 1996·The Journal of Clinical Investigation·M KlinS G Massry
Sep 1, 1996·Kidney International·N D Vaziri, K H Liang
Mar 1, 1997·Kidney International·N D Vaziri, K Liang
Jun 1, 1997·Kidney International·K Liang, N D Vaziri

❮ Previous
Next ❯

Citations

Feb 21, 1998·Lipids·A KambeY Adachi
Jul 29, 1998·Disease-a-month : DM·L M Antes, P C Fernandez
Feb 22, 2012·Nature Reviews. Nephrology·Murray Epstein, Nosratola D Vaziri
Jul 21, 1999·Kidney International. Supplement·G A Kaysen, M G de Sain-van der Velden
Apr 23, 2002·Kidney International·Nosratola D Vaziri, Kaihui Liang
Apr 5, 2003·Kidney International·Nosratola D Vaziri
Apr 5, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nosratola D VaziriHamid Moradi
Dec 19, 2009·Seminars in Dialysis·Nosratola D Vaziri
Feb 28, 2013·International Urology and Nephrology·Georges KhoueiryJames Lafferty
May 20, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Nosratola D Vaziri, Hamid Moradi
Nov 17, 2015·Nature Reviews. Nephrology·Nosratola D Vaziri
Dec 1, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G C ShearerG A Kaysen
Jan 31, 2006·Hemodialysis International·Nosratola D Vaziri, Hamid Moradi
Nov 14, 1997·The Journal of Laboratory and Clinical Medicine·K Liang, N D Vaziri
Jun 1, 2000·Metabolism: Clinical and Experimental·K NakayamaS Kakumu
May 27, 2015·Archives of Medical Research·Valentina KonSergio Fazio
May 12, 2016·Kidney International·Nosratola D Vaziri
Oct 28, 2004·The Annals of Pharmacotherapy·William A PrescottDaniel S Streetman
Jul 16, 2004·Kidney International·Bernardo Rodríguez-IturbeNosratola D Vaziri
Dec 9, 2004·American Journal of Physiology. Endocrinology and Metabolism·Sara KimNosratola D Vaziri
Feb 1, 2007·Arthritis and Rheumatism·Talin SarkissianEarl D Silverman
Aug 3, 2005·Medicinal Research Reviews·Michele BuemiNicola Frisina
Mar 11, 2006·American Journal of Physiology. Renal Physiology·Gregory R Adams, Nosratola D Vaziri
Mar 17, 2018·Current Medicinal Chemistry·Alice OssoliMonica Gomaraschi
Oct 26, 2012·Journal of Atherosclerosis and Thrombosis·William F KeaneDavid R Neff
Mar 17, 1999·Journal of Atherosclerosis and Thrombosis·J Fan, T Watanabe
Apr 9, 2001·American Journal of Physiology. Renal Physiology·N D VaziriJ S Parks
Jan 27, 2019·Journal of Cachexia, Sarcopenia and Muscle·Fabrizio PinThomas M O'Connell
May 1, 2021·Life·Carlo Maria BarbagalloEmilio Nardi
Apr 14, 2005·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Florian Kronenberg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.