Down-regulation of IGF-1/IGF-1R in hippocampus of rats with vascular dementia

Neuroscience Letters
Xiuqun GongGelin Xu

Abstract

Insulin-like growth factor-1 (IGF-1) has been demonstrated to have neuroprotective effects, but little is known concerning its role in vascular dementia (VaD). This study aimed to evaluate expression of IGF-1 signaling in hippocampus in rat model of VaD, and probe the underlying mechanisms. Permanent occlusion of bilateral common carotid arteries (2-VO) was used as VaD model. Learning and memory functions were declined significantly in 2-VO rats, and these impairments were further deteriorated with the prolongation of 2-VO treatment. IGF-1, IGF-1 receptor (IGF-1R), total Akt and phosphorylated Akt (p-Akt) were all measured at 1, 2 and 4 months following 2-VO injury. Compared with controls, IGF-1, IGF-1 mRNA and p-Akt expression were significantly decreased in hippocampus of 2-VO rats. However, changes of IGF-1R and total Akt levels were not significant. These results suggest that down-regulation of IGF-1 and p-Akt may contribute to the impairments of learning and memory functions after 2-VO. IGF-1/IGF-1R signaling system may involved in the onset and development of VaD.

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Citations

Oct 12, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Yanzhen ZhuXiaobao Ye
Nov 15, 2012·Journal of Translational Medicine·Juan E Puche, Inma Castilla-Cortázar
Oct 25, 2012·The Journal of Endocrinology·Alfhild GrönbladhMathias Hallberg
Sep 12, 2015·The Tohoku Journal of Experimental Medicine·Lin WuXin-Kun Cai
Jun 25, 2014·Journal of Asian Natural Products Research·Cui-Ge ShiShu-Cheng Zhang
Jan 30, 2014·Acta Cirúrgica Brasileira·Maria Cecília Santos Cavalcanti MeloCarlos Teixeira Brandt
May 18, 2019·International Journal of Molecular Sciences·Jakub HortFrancesco Angelucci
Jan 20, 2017·Experimental and Therapeutic Medicine·Ying ZhangShu-Cheng Zhang
Feb 13, 2020·Journal of Translational Medicine·Inma Castilla-CortázarLuis Espinosa
Mar 25, 2014·Experimental and Therapeutic Medicine·Zhi-Kun SunBo-Ai Zhang

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