Down-regulation of let-7 microRNA increased K-ras expression in lung damage induced by radon

Environmental Toxicology and Pharmacology
Zhi-Hai ChenJihua Nie

Abstract

Radon has long been recognized as a human carcinogen leading to lung cancer, but the underlying mechanisms remain obscure. Recent studies have shown that the let-7 microRNA and K-ras play an important role in the development of various cancers. However, the exact role between let-7 and K-ras in radon induced lung damage has not been explored so far. In the present study, wistar rats and human bronchial epithelial (HBE) cells were long-term exposed to radon, and then alterations in histological pathology of rat lung tissue, ROS, antioxidant enzymes activities and clonogenic formation in HBE cells, as well as changes in let-7 and K-ras expression were determined to observe the adverse effects induced by radon. The results showed that long-term exposure to radon produced severe lung damage in rats, significantly increased ROS production and clonogenic formation ratios and decreased SOD activities in HBE cells. In addition, an obvious down-regulation of let-7 and up-regulation of K-ras were also revealed both in mRNA and in protein level in lung tissue of rats and HBE cells exposed to radon. Furthermore, a significant down-regulation of K-ras was then confirmed in both let-7b-3p and let-7a-2-3p transfected HBE cells. Taken together...Continue Reading

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Jun 9, 2016·Journal of Toxicology and Environmental Health. Part a·Xing LiuJian Tong
Jan 25, 2019·International Journal of Radiation Biology·Michelle BugdenYi Wang
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Apr 4, 2021·Biomedicines·Ying-Chin LinJung-Chun Lin

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