Down regulation of miR-18a, miR-21 and miR-221 genes in gastric cancer cell line by chrysin-loaded PLGA-PEG nanoparticles

Artificial Cells, Nanomedicine, and Biotechnology
Farideh MohammadianNosratollah Zarghami

Abstract

Chrysin were well-documented as having significant biological roles particularly cancer chemo-preventive activity. However, the poor water solubility of chrysin limited their bioavailability and biomedical applications. In this study, we encapsulate the chrysin into PLGA-PEG nanoparticles for local treatment. In regard to the amount of the drug load, IC50 was significant decreased in nanocapsulated chrysin in comparison with free chrysin. This was confirmed through decrease of miR-18a, miR-21, and miR-221 genes expression by real-time PCR. The results demonstrated that PLGA-PEG-chrysin complexes can be more effective than free chrysin. Therefore, PLGA-PEG can be a better nanocarrier for this kind of hydrophobic flavonoid.

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Citations

Sep 30, 2016·Artificial Cells, Nanomedicine, and Biotechnology·Farideh MohammadianNosratollah Zarghami
Oct 25, 2016·International Journal of Pharmaceutics·Shital LungareRaj K S Badhan
Jan 13, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Soumaye AmirsaadatNosratollah Zarghami
Jul 6, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Raana FarajzadehNosratollah Zarghami
Jul 14, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Yebin LuWei Wei
Sep 22, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Neda NaseriYounes Pilehvar-Soltanahmadi
Aug 24, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Reza ZamaniNosratollah Zarghami
Jan 5, 2019·Journal of Cellular Physiology·Arman ShahabiNosratollah Zarghami
Mar 21, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Leila FaramarziNosratollah Zarghami
Oct 1, 2020·Biomolecules·Ebrahim Rahmani MoghadamAlan Prem Kumar
Apr 3, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Fatemeh TavakoliNosratollah Zarghami
Feb 14, 2020·Current Stem Cell Research & Therapy·Saba SameriRazieh Amini
Jun 3, 2018·Cell and Tissue Banking·Caiyun MaWeijun Guan
Aug 3, 2019·Seminars in Cancer Biology·Haroon KhanMohammad Amjad Kamal
Feb 8, 2021·Journal of Cancer Research and Clinical Oncology·Lanxin JiangRunwei Yan
Oct 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ayesha Atiq, Ishwar Parhar
Nov 13, 2020·Clinical and Experimental Gastroenterology·Khadijeh Kalan FarmanfarmaHamid Salehiniya
Apr 17, 2021·Cancer Cell International·Marjan TalebiSaeed Samarghandian
Jul 20, 2021·Archives of Virology·Jiulue HuHamed Serati-Nouri
Jul 3, 2020·Current Pharmaceutical Design·Mehak JindalGitika Arora Dhingra
Oct 1, 2021·Drug Development and Industrial Pharmacy·Yong QuGuohua Zheng
Sep 2, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Fatemeh MemariNosratollah Zarghami
Jun 18, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Akram Firouzi-AmandiYounes Pilehvar-Soltanahmadi
Jul 20, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hassan MellatyarNosratollah Zarghami

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