Down-regulation of Notch-1 is associated with Akt and FoxM1 in inducing cell growth inhibition and apoptosis in prostate cancer cells.

Journal of Cellular Biochemistry
Zhiwei WangFazlul H Sarkar

Abstract

Although many studies have been done to uncover the mechanisms by which down-regulation of Notch-1 exerts its anti-tumor activity against a variety of human malignancies, the precise molecular mechanisms remain unclear. In the present study, we investigated the cellular consequence of Notch-1 down-regulation and also assessed the molecular consequence of Notch-1-mediated alterations of its downstream targets on cell viability and apoptosis in prostate cancer (PCa) cells. We found that the down-regulation of Notch-1 led to the inhibition of cell growth and induction of apoptosis, which was mechanistically linked with down-regulation of Akt and FoxM1, suggesting for the first time that Akt and FoxM1 are downstream targets of Notch-1 signaling. Moreover, we found that a "natural agent" (genistein) originally discovered from soybean could cause significant reduction in cell viability and induced apoptosis of PCa cells, which was consistent with down-regulation of Notch-1, Akt, and FoxM1. These results suggest that down-regulation of Notch-1 by novel agents could become a newer approach for the prevention of tumor progression and/or treatment, which is likely to be mediated via inactivation of Akt and FoxM1 signaling pathways in PCa.

References

Feb 21, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lucio Miele
Mar 21, 2006·Molecular Cancer Therapeutics·Zhiwei WangFazlul H Sarkar
Jul 11, 2006·International Journal of Cancer. Journal International Du Cancer·Yuxiang ZhangFazlul H Sarkar
Jul 20, 2006·Current Cancer Drug Targets·L MieleB J Nickoloff
Oct 5, 2006·Cancer Research·Senthil K RadhakrishnanAndrei L Gartel
Nov 30, 2006·International Journal of Cancer. Journal International Du Cancer·Sanjeev BanerjeeFazlul H Sarkar
Dec 7, 2007·Laboratory Investigation; a Journal of Technical Methods and Pathology·Clodia OsipoLucio A Miele
Apr 17, 2008·Cell Cycle·Teresa PalomeroAdolfo A Ferrando
May 16, 2008·Expert Opinion on Therapeutic Targets·Andrei L Gartel
May 22, 2008·Cancer Letters·Sanjeev BanerjeeFazlul H Sarkar
Jun 21, 2008·Differentiation; Research in Biological Diversity·Kevin G Leong, Wei-Qiang Gao
Sep 2, 2008·Oncogene·P RizzoL Miele
Nov 11, 2008·Current Cancer Drug Targets·M A VillarongaB Belandia
Jan 17, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Bilal Bin HafeezHasan Mukhtar
Apr 22, 2009·Cell·Raphael Kopan, Maria Xenia G Ilagan
May 29, 2009·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Jun 3, 2009·Cancer Treatment Reviews·Cristina FalciJean Pierre Droz
Aug 22, 2009·The EMBO Journal·Hyun Jung ParkPradip Raychaudhuri
Dec 22, 2009·Cancer Treatment Reviews·Zhiwei WangFazlul H Sarkar
Jan 16, 2010·Expert Opinion on Investigational Drugs·Andrei L Gartel

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Citations

Sep 6, 2011·Journal of Molecular Histology·Renhua FanFeng Liu
Jan 18, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Dongye LiuChui-ze Kong
Dec 12, 2013·Molecular Cancer·Ming QuanKeping Xie
Oct 24, 2013·Journal of Translational Medicine·MinRan ZhouChunYan Chen
Jan 7, 2014·Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis·Harold TingRajesh Agarwal
Mar 6, 2013·Pharmacology & Therapeutics·Ingrid Espinoza, Lucio Miele
Nov 30, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·P AccialiniM Tesone
Oct 1, 2013·Drug Delivery and Translational Research·Prasad DandawateFazlul H Sarkar
May 9, 2015·Seminars in Cancer Biology·Abbas K SamadiXujuan Yang
Mar 5, 2015·Journal of Cancer Research and Clinical Oncology·Gang DengZhijian Yu
Oct 30, 2012·Biochemical Pharmacology·Marianna Halasi, Andrei L Gartel
Apr 27, 2011·Journal of Cellular Biochemistry·Thomas YongJ Nathan Davis
Oct 15, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Erik G HuntzickerDorothy M French
Sep 4, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Qi-Fa YeLe-Ye He
Aug 11, 2012·Expert Opinion on Therapeutic Targets·Bin BaoFazlul H Sarkar
Jul 15, 2015·Bioorganic & Medicinal Chemistry·Yi ChenNelson N H Teng
Jun 28, 2011·The American Journal of Pathology·Qi LongCarlos S Moreno
Jun 14, 2016·The Journal of Clinical Investigation·Oh-Joon KwonLi Xin
Sep 23, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jian ShaWenyao Lin
Dec 8, 2015·PloS One·Azusa MiyashitaHironobu Ihn
May 4, 2018·Phytotherapy Research : PTR·Jae Hee LeeSung-Hoon Kim
Aug 14, 2013·Laboratory Investigation; a Journal of Technical Methods and Pathology·Ryoji YoshidaTakaaki Ito
Aug 20, 2018·Endocrine-related Cancer·Lautaro Zubeldía-BrennerDamasia Becu-Villalobos
Aug 20, 2014·Nature Reviews. Urology·Angela N FloresLaure Marignol
May 29, 2013·Nature Reviews. Urology·Laure MarignolDonal Hollywood

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