Down-regulation of NR2B receptors partially contributes to analgesic effects of Gentiopicroside in persistent inflammatory pain

Neuropharmacology
Lei ChenMing-Gao Zhao

Abstract

Gentiopicroside is one of the secoiridoid compound isolated from Gentiana lutea. It exhibits analgesic activities in the mice. The anterior cingulate cortex (ACC) is a forebrain structure known for its roles in pain transmission and modulation. Painful stimuli potentiate the prefrontal synaptic transmission and induce glutamate NMDA NR2B receptor expression in the ACC. But little is known about Gentiopicroside on the persistent inflammatory pain and chronic pain-induced synaptic transmission changes in the ACC. The present study was undertaken to investigate its analgesic activities and central synaptic modulation to the peripheral painful inflammation. Gentiopicroside produced significant analgesic effects against persistent inflammatory pain stimuli in mice. Systemic administration of Gentiopicroside significantly reversed NR2B over-expression during the chronic phases of persistent inflammation caused by hind-paw administration of complete Freunds adjuvant (CFA) in mice. Whole-cell patch clamp recordings revealed that Gentiopicroside significantly reduced NR2B receptors mediated postsynaptic currents in the ACC. Our findings provide strong evidence that analgesic effects of Gentiopicroside involve down-regulation of NR2B rec...Continue Reading

Citations

Jun 8, 2011·Clinical and Experimental Pharmacology & Physiology·Shui-Bing LiuMing-Gao Zhao
Jan 21, 2016·European Journal of Cell Biology·Zilin LiJincheng Liu
Sep 11, 2009·Luminescence : the Journal of Biological and Chemical Luminescence·Xili HeZhenghua Song
Jan 6, 2015·Journal of Pharmaceutical and Biomedical Analysis·Zhigang WangNing Zhang
Aug 21, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Zhen TianShui-bing Liu
May 31, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Yan ChenQianqian Liang
Mar 7, 2017·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Pere Boadas-VaelloEnrique Verdú
Mar 4, 2017·European Journal of Medicinal Chemistry·Shaoping WuYongmin Zhang
Oct 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Laura GuedesMaria Luísa Serralheiro

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here