PMID: 9178810May 16, 1997Paper

Down-regulation of protein and mRNA expression for transforming growth factor-beta (TGF-beta1) type I and type II receptors in human prostate cancer

International Journal of Cancer. Journal International Du Cancer
Y GuoN Kyprianou

Abstract

Transforming growth factor-beta (TGF-beta1) is a potent negative regulator of cell growth that transduces signals through interactions with type I and II receptors. Abnormal expression and mutational alterations of these receptors have been observed in several human malignancies. In this study, we investigated the expression of the two types of TGF-beta1 receptors, R-I and R-II, in a normal human prostate, primary prostate adenocarcinoma and lymph nodes with metastatic deposits. Expression of receptor proteins was examined by immunohistochemical analysis in paraffin-embedded prostatic tissue sections, and mRNA expression was determined by Northern blot and RT-PCR analysis. Uniformly strong immunoreactivity for both TGF-beta receptor proteins, R-I and R-II, was exclusively localized to the prostatic glandular epithelium of normal prostates. In contrast, tumor epithelial cells in primary and metastatic prostatic cancer specimens exhibited a weak heterogeneous immunoreactivity for both R-I and R-II receptors; 25% of primary prostatic tumors and 45% of the lymph nodes with metastases were totally negative for R-I and R-II expression, while the rest exhibited a significantly reduced immunoreactivity for both types of receptors compa...Continue Reading

References

Mar 1, 1989·Molecular and Cellular Endocrinology·G WildingE Gelmann
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·M E KadinD George
Aug 4, 1994·Nature·J L WranaJ Massagué
Oct 21, 1996·International Journal of Cancer. Journal International Du Cancer·H TuN Kyprianou
May 1, 1994·Trends in Cell Biology·J MassaguéJ L Wrana

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Citations

Mar 22, 2014·PloS One·Glen A BjerkeDavid Wotton
Jul 19, 2013·Pharmacology & Therapeutics·Ayesha A ShafiNancy L Weigel
Mar 17, 2001·Journal of Clinical Pathology·A FranchiM Santucci
Nov 3, 2011·World Journal of Gastroenterology : WJG·Shilpa JainRu-Liang Xu
Mar 15, 2008·The International Journal of Biochemistry & Cell Biology·Leileata M RussoHerbert Y Lin
Nov 8, 2016·Scientific Reports·Kenji YumotoRussell S Taichman
Apr 29, 1998·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M J GerdesD R Rowley
Jun 29, 2000·Medical Oncology·S N PentyalaS A Khan
Dec 23, 2003·Journal of Cellular Biochemistry·Brian Nicholson, Dan Theodorescu
Sep 8, 2004·International Journal of Cancer. Journal International Du Cancer·Ignacio F San FranciscoAria F Olumi
Oct 21, 2004·Cancer·David G BostwickBarry Timms
Mar 22, 2006·Prostate Cancer and Prostatic Diseases·M C PerttuH Syvälä
Dec 18, 2019·Cells·Joanna BoguslawskaAgnieszka Piekielko-Witkowska
Jan 10, 2001·Current Opinion in Oncology·R Wieser
Oct 5, 2001·Nature Genetics·R DerynckA Balmain
Nov 10, 2015·Future Oncology·Seth A Broster, Natasha Kyprianou
Mar 27, 2018·The Prostate·W Nathaniel Brennen, John T Isaacs
Feb 22, 2002·BJU International·G O Hellawell, S F Brewster
Nov 25, 2004·The Journal of Biological Chemistry·Hui WangDavid Danielpour
Jul 25, 2008·The Biochemical Journal·Wei QiZhengxin Wang
Jan 24, 2014·Cancer Metastasis Reviews·Magdalena M GrabowskaRobert J Matusik
Mar 19, 2014·Journal of Cellular and Molecular Medicine·Luís Korrodi-GregórioMargarida Fardilha
Jan 7, 2014·Journal of Zhejiang University. Science. B·Juliana FelgueirasMargarida Fardilha
Jun 21, 2018·Nutrients·Ivan V Maly, Wilma A Hofmann
Sep 5, 2012·Journal of Translational Medicine·Lenka KubiczkovaSabina Sevcikova
Feb 15, 2012·Cancer Immunology, Immunotherapy : CII·Nicolò Rigamonti, Matteo Bellone

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