PMID: 9556213Apr 29, 1998Paper

Down-regulation of protein kinase C-alpha detected in human colorectal cancer

Biochemistry and Molecular Biology International
K SugaE Hashimoto

Abstract

The down-regulation of protein kinase C (PKC) was examined by Western blot procedure on about 30 tissue samples derived from human colorectal cancer and the corresponding normal mucosa. PKC-alpha down-regulation was detected in 60% of the cancer tissues compared with the respective normal mucosa and was observed in a higher frequency with the tissues under more advanced cancer stages. However, the frequencies of the down-regulation of PKC-delta and PKC-zeta were lower than that of PKC-alpha. These results suggest that a decreased level of PKC-alpha may affect the cell growth and tumor promotion in colorectal tissue.

Citations

Dec 23, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M LahnD Ma
Jun 27, 2006·Seminars in Oncology·George W Sledge, Yesim Gökmen-Polar
Jan 22, 2020·Journal of Cellular and Molecular Medicine·Minzi DengHeli Liu
Jan 10, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Feng QiJianguo Gu
May 5, 2009·The Oncologist·Angelo DelmonteCristiana Sessa
Jun 23, 2007·Nature Reviews. Cancer·Helen J Mackay, Christopher J Twelves

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