PMID: 6403789Mar 28, 1983Paper

Down regulation of striatal dopamine receptors in experimental hepatic encephalopathy

Life Sciences
M BaraldiE Ventura

Abstract

Dopamine receptors were studied in striatal synaptosomes prepared from rat brain with hepatic encephalopathy induced by galactosamine-HCl and documented by visual evoked potential recordings. In order to further characterize the model, plasma amino acid levels and striatal catecholamines and octopamine levels were assayed. In agreement with previous reports in animal and in man, plasma amino acids were increased both in mild and severe stage of this pathology. Striatal levels of norepinephrine and dopamine fell during the development of coma while octopamine rose. Dopamine binding studies showed a decrease in the affinity during the mild stage and a reduction of receptor numbers in the severe stage of encephalopathy. The overall results, in the light of previous reports on GABA receptor studies, seem to indicate the presence in the development of encephalopathy of an imbalance between the dopaminergic and the GABAergic system leading to a prevalence of GABAergic inhibitory system.

References

Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·M TitelerP Seeman
Jul 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L Zieve
Jan 3, 1983·Brain Research·M BaraldiM L Zeneroli

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Citations

Nov 14, 1997·Lancet·R Jalan, P C Hayes
Jul 1, 1995·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·M BaraldiA Corti
Nov 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E A JonesS C Pappas
Feb 1, 1990·Neurochemical Research·M Baraldi
Jan 27, 2006·Chemical Senses·Gesualdo M ZuccoAngelo Gatta

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