Down-regulation of survivin by oxaliplatin diminishes radioresistance of head and neck squamous carcinoma cells

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Zakir KhanPrakash S Bisen

Abstract

Oxaliplatin is integrated in treatment strategies against a variety of cancers including radiation protocols. Herein, as a new strategy we tested feasibility and rationale of oxaliplatin in combination with radiation to control proliferation of head and neck squamous cell carcinoma (HNSCC) cells and discussed survivin-related signaling and apoptosis induction. Cytotoxicity and apoptosis induced by radiation and/or oxaliplatin were examined in relation to survivin status using two HNSCC cell lines viz., Cal27 and NT8e, and one normal 293-cell line. Survivin gene knockdown by siRNA was also tested in relevance to oxaliplatin-mediated radiosensitization effects. Survivin plays a critical role in mediating radiation-resistance in part through suppression of apoptosis via a caspase-dependent mechanism. Oxaliplatin treatment significantly decreased expression of survivin in cancer cells within 24-72 h. Apoptotic cells and caspase-3 activity were increased parallely with decrease in cell viability, if irradiated during this sensitive period. The cytotoxicity of oxaliplatin and radiation combination was greater than additive. Survivin gene knockdown experiments have demonstrated the role of survivin in radiosensitization of cancer cell...Continue Reading

References

Jul 1, 1989·Archives of Otolaryngology--head & Neck Surgery·D E SchullerB Metch
Oct 15, 1995·International Journal of Radiation Oncology, Biology, Physics·L X YangH J Wang
Apr 30, 1993·International Journal of Radiation Oncology, Biology, Physics·L J PetersR A Frankenthaler
May 1, 1996·European Journal of Cancer. Part B, Oral Oncology·H Raybaud-DiogèneR A Monteil
Jun 6, 1998·The Journal of Biological Chemistry·G AmbrosiniD C Altieri
Dec 14, 1999·The Journal of Investigative Dermatology·D GrossmanD C Altieri
Feb 10, 2000·The American Journal of Pathology·D S O'ConnorD C Altieri
Apr 13, 2000·International Journal of Radiation Oncology, Biology, Physics·G P AmorinoH Choy
Jun 22, 2001·Experimental and Molecular Pathology·L Lo MuzioD C Altieri
Oct 3, 2002·Japanese Journal of Cancer Research : Gann·Koichi AsanumaNaoki Watanabe
Mar 22, 2003·The Journal of Investigative Dermatology·Marzia PennatiNadia Zaffaroni
Aug 28, 2003·Journal of Cellular Physiology·Fengzhi Li
Mar 16, 2004·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Wanguang ZhangFazu Qiu
Apr 17, 2004·Cancer Research·Bo LuDennis E Hallahan
Oct 18, 2005·Molecular Cancer Therapeutics·Taishi HataMorito Monden
Apr 20, 2006·Cancer Letters·N K SahP S Bisen
Nov 14, 2007·Journal of Cancer Research and Therapeutics·Veenita Yogi, O P Singh

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Citations

Apr 23, 2013·Biochimica Et Biophysica Acta·Zakir Khan, Prakash S Bisen
Apr 10, 2014·Apoptosis : an International Journal on Programmed Cell Death·Bettina M KaminskiSandra Ulrich-Rückert
May 20, 2014·Molecular Diagnosis & Therapy·Anubhav JainPrakash S Bisen
Jun 23, 2012·Molecular Cancer Therapeutics·Bhavna KumarPawan Kumar
Nov 26, 2013·Oral Oncology·Heng-Wei HsuSaied Mirshahidi
Jan 10, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Zakir KhanPrakash Singh Bisen
Apr 11, 2012·Journal of Biomedical Materials Research. Part a·Jan Ortiz, Laisheng Lee Chou
Dec 25, 2012·Journal of Experimental & Clinical Cancer Research : CR·Ji-Yu LiXing-Song Tian
Jun 28, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Sergej SkvortsovPeter Lukas
Aug 20, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Sebastian ReichertFranz Rödel
Jul 5, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·H Peter Rodemann, Bradly G Wouters
Sep 11, 2012·Pediatric Blood & Cancer·Pooja HingoraniDavid O Azorsa
Apr 10, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Kezban Esra KekilliLutfi Ozkan
Feb 23, 2018·Oncology Letters·Roman C BrandsUrs D A Müller-Richter
May 26, 2017·Cellular & Molecular Biology Letters·Zakir KhanPrakash Singh Bisen
Dec 8, 2016·Journal of Biomedical Science·Najmeh RahmanianAli Khalaj
Aug 8, 2019·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Mario J J ScheurerRoman C Brands

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