Down-regulation of the CYP19A1 gene in cumulus cells of infertile women with endometriosis

Reproductive Biomedicine Online
Ionara Diniz Evangelista Santos BarcelosPaula Andrea Navarro

Abstract

Aromatase plays a fundamental role in the establishment of oocyte quality, which might be compromised in infertile women with endometriosis. The expression of the CYP19A1 gene (that encodes aromatase) was compared in cumulus cells and oestradiol concentrations in the follicular fluid of infertile women with and without endometriosis submitted to ovarian stimulation for intracytoplasmic sperm injection. Cumulus cells were isolated and the expression of the CYP19A1 was quantitated through real-time polymerase chain reaction. Oestradiol concentrations in follicular fluid were measured by chemiluminescence immunoassay. A lower expression of the CYP19A1 in the cumulus cells of infertile women with endometriosis was observed compared with controls (0.17 ± 0.13 and 0.56 ± 0.12, respectively), and no significant difference in the follicular fluid oestradiol concentrations was observed between groups. Our results show reduced expression of the CYP19A1 in cumulus cells of infertile women with endometriosis, which may play a role in the pathogenesis of endometriosis-related infertility.

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Citations

Dec 22, 2015·Cell and Tissue Research·Michele Gomes Da Broi, Paula Andrea Navarro
May 12, 2016·Journal of Assisted Reproduction and Genetics·Elham HosseiniReza Aflatoonian
Oct 19, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Marco D'AuroraValentina Gatta
Nov 7, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·Richard J Kordus, Holly A LaVoie
Mar 3, 2018·Journal of Assisted Reproduction and Genetics·M G Da BroiP A Navarro
Aug 18, 2018·Experimental and Therapeutic Medicine·Loukia VassilopoulouGeorge N Goulielmos
Apr 17, 2019·Experimental and Therapeutic Medicine·Loukia VassilopoulouGeorge N Goulielmos
May 11, 2018·Oxidative Medicine and Cellular Longevity·Salvatore Giovanni VitaleGabriella Zito
Dec 29, 2020·Reproductive Biomedicine Online·Liliane Fabio Isidoro da SilvaPaula Andrea Navarro
Mar 20, 2021·Reproductive Biomedicine Online·Caroline M Da LuzPaula A Navarro
Jul 24, 2021·Evolutionary Applications·Natalie L Dinsdale, Bernard J Crespi

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