Down-regulation of the mdr gene by thyroid hormone during Xenopus laevis development

Molecular and Cellular Endocrinology
S N ZuckerS Band Horwitz

Abstract

The developmental regulation of mdr in Xenopus laevis has been investigated. Xe-mdr expression was first detected in the early tadpole stage just prior to the onset of feeding and increased during intestinal development, with a sharp decline at metamorphosis. Xe-mdr expression was found to be localized specifically to the epithelial cells lining the intestinal tract. When premetamorphic tadpoles were treated with 5 nM triiodothyronine to induce metamorphosis, a significant decrease in mdr message and protein was observed after 3 days, a time at which the primary epithelium remained intact. Furthermore, in thyroid-hormone treated primary cultures of brush border epithelial cells, a reduction in mdr message also was observed. These results demonstrate that the Xe-mdr gene is developmentally regulated and suggest a role for thyroid hormone in this process. This is the first report of a naturally occurring substance that can down-regulate mdr gene expression in vivo.

References

Jan 1, 1992·Annual Review of Cell Biology·C F Higgins
Jan 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A T FojoI Pastan
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·F ThiebautM C Willingham
Mar 1, 1989·Molecular and Cellular Biology·W F NgV Ling
Jan 1, 1989·Annual Review of Biochemistry·J A Endicott, V Ling
Sep 1, 1989·Molecular and Cellular Biology·J E ChinI B Roninson
Dec 23, 1988·Nucleic Acids Research·K YoshimotoI Pastan
Nov 30, 1988·Gene·A M van der BliekP Borst
May 1, 1988·The Journal of Clinical Investigation·J M CroopD E Housman
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R J ArceciD Housman
Jul 1, 1988·Molecular and Cellular Biology·P GrosD Housman
Jan 1, 1967·Recent Progress in Hormone Research·E Frieden
Apr 28, 1995·The Journal of Biological Chemistry·F J SharomK J Ashbourne
May 1, 1995·The EMBO Journal·A BroeksR H Plasterk
Jan 1, 1993·Advances in Pharmacology·Z C Gatmaitan, I M Arias
Jan 1, 1993·Annual Review of Biochemistry·M M Gottesman, I Pastan
Mar 1, 1994·Biochimica Et Biophysica Acta·Y B Shi, V C Liang
Jun 1, 1994·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·D S ReillyM Zasloff

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood-Brain Barrier Transport in Neurodegeneration

The blood brain barrier is important for regulating the movement of biomolecules in and out of the brain. For example, membrane transporters in the blood brain barrier can be essential for regulating drug movement and dysregulation of these processes may play a role in neurodegeneration. This feed follows the latest research on this topic.

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.