Down-regulation of traditional oncomiRs in plasma of breast cancer patients

Oncotarget
Dana JurkovicovaIvana Fridrichova

Abstract

Deregulated expression of microRNAs has the oncogenic or tumor suppressor function in cancer. Since miRNAs in plasma are highly stable, their quantification could contribute to more precise cancer diagnosis, prognosis and therapy prediction. We have quantified expression of seven oncomiRs, namely miR-17/92 cluster (miR-17, miR-18a, miR-19a and miR-20a), miR-21, miR-27a and miR-155, in plasma of 137 breast cancer (BC) patients. We detected down-regulation of six miRNAs in patients with invasive BC compared to controls; however, only miR-20a and miR-27a down-regulations were statistically significant. Comparing miRNA expression between early and advanced stages of BC, we observed statistically significant decrease of miR-17 and miR-19a. We identified down-regulation of miR-17 and miR-20a in patients with clinical parameters of advanced BC (lymph node metastasis, tumor grade 3, circulating tumor cells, higher Ki-67-related proliferation, hormone receptor negativity and HER2 amplification), when compared to controls. Moreover, decreased level of miR-17 was found from low to high grade. Therefore, miR-17 could represent an indicator of advanced BC. Down-regulated miR-27a expression levels were observed in all clinical categories reg...Continue Reading

References

Aug 30, 2000·Nature·C M PerouD Botstein
Oct 27, 2001·Science·M Lagos-QuintanaT Tuschl
Jun 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Therese SorlieDavid Botstein
Jun 24, 2004·Nature Reviews. Genetics·Lin He, Gregory J Hannon
Jun 10, 2005·Nature·Lin HeScott M Hammond
Jun 10, 2005·Nature·Jun LuTodd R Golub
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Stefano VoliniaCarlo M Croce
Aug 31, 2006·Molecular and Cellular Biology·Anwar HossainGrady F Saunders
Jun 15, 2007·Nature Structural & Molecular Biology·Sonia Guil, Javier F Cáceres
Jul 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Patrick S MitchellMuneesh Tewari
Feb 26, 2009·Cell·Andrea Ventura, Tyler Jacks
Mar 30, 2010·Journal of Experimental & Clinical Cancer Research : CR·Bao SongXianrang Song
Apr 1, 2010·The Journal of Biological Chemistry·Nobuyoshi KosakaTakahiro Ochiya
Apr 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Zuoren YuRichard G Pestell
May 4, 2010·Biogerontology·Johannes GrillariRegina Grillari-Voglauer
Sep 4, 2010·Breast Cancer Research : BCR·Aleix PratCharles M Perou
Nov 5, 2010·Breast Cancer Research : BCR·Carina RothHeidi Schwarzenbach
Nov 9, 2010·Cancer Biology & Therapy·Gautam K MalhotraVimla Band
Mar 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jason D ArroyoMuneesh Tewari
May 19, 2011·Cancer Research·Thalia A FaraziThomas Tuschl
Nov 23, 2011·Journal of Surgical Oncology·Jian ChenJin-Hai Tang
Dec 14, 2011·Cancer Prevention Research·Colin C PritchardMuneesh Tewari
Aug 10, 2012·Molecular BioSystems·Xing ChenGui-Ying Yan
Sep 4, 2013·Biotechnology Advances·Hadi EsmaeilsabzaliEdward J Park
Jun 29, 2014·BMC Cancer·Zuzana CiernaJozef Mardiak

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Citations

Mar 19, 2019·British Journal of Pharmacology·Chiara Bianca Maria PlataniaClaudio Bucolo
Nov 7, 2019·Cells·Ivana Fridrichova, Iveta Zmetakova
Aug 23, 2020·International Journal of Molecular Sciences·Anna Maria GrimaldiMariarosaria Incoronato
Feb 19, 2020·Molecular Diagnosis & Therapy·Vaishali AggarwalHardeep Singh Tuli
Jun 14, 2019·Journal of Oncology·Jarline Encarnación-MedinaJaime Matta

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Methods Mentioned

BETA
biopsies
Assay
PCR

Software Mentioned

RWRMDA
RWRMDA Association

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