PMID: 9553046May 30, 1998Paper

Down-regulation of transcription factor CF2 by Drosophila Ras/MAP kinase signaling in oogenesis: cytoplasmic retention and degradation

Genes & Development
E Y Mantrova, T Hsu

Abstract

Dorsoventral (D/V) patterning in Drosophila oogenesis is initiated by the transmission of a TGF-alpha-like ligand, Gurken (Grk), from the oocyte to the anterodorsal follicle cells, activating the EGF receptor (Egfr) signaling pathway. The zinc-finger transcription factor CF2 is a negative regulator of the rhomboid (rho) gene that encodes an essential membrane-bound component of the dorsalizing pathway. Expression of CF2 itself is negatively regulated by the activated Egfr. In this report, we demonstrate that CF2 is the target of down-regulation by the MAPK kinase cascade, and that this down-regulation is independent of the Rho function. These results suggest that D/V patterning involves a two-step signaling process: the initial Egfr signal, which represses CF2 and induces rho expression; and the subsequent Egfr + Rho signal, which determines the dorsal cell fates. Furthermore, we show that CF2 down-regulation occurs at the post-translational level through a mechanism involving coupled cytoplasmic retention and degradation.

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Citations

Feb 10, 2012·Acta Biotheoretica·L Almeida, J Demongeot
Dec 28, 2007·Molecular and Cellular Biology·Kathleen K Kelly TanakaRichard M Cripps
Jan 1, 2010·Annual Review of Chemical and Biomolecular Engineering·Jeremiah J Zartman, Stanislav Y Shvartsman
Mar 29, 2014·PLoS Computational Biology·Adrien FauréClaudine Chaouiya
Oct 16, 1999·Proceedings of the National Academy of Sciences of the United States of America·E Y MantrovaT Hsu
Feb 11, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Katherine C JordanHannele Ruohola-Baker
Jan 27, 2007·The EMBO Journal·Sergio AstigarragaGerardo Jiménez
Jul 25, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Valeria CavaliereGiuseppe Gargiulo
Jan 28, 2003·Biophysical Journal·Michal PribylStanislav Y Shvartsman
Jun 5, 2001·Nature Cell Biology·M Freeman
Apr 22, 2003·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Vincent Dammai, Tien Hsu
Apr 27, 2012·Comparative and Functional Genomics·Yanping QuanYaozhou Zhang
Jun 6, 2008·The Journal of Biological Chemistry·Nirotpal Mrinal, Javaregowda Nagaraju

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