PMID: 8962162Dec 10, 1996Paper

Down-regulation of transcripts for Na channel alpha-SNS in spinal sensory neurons following axotomy

Proceedings of the National Academy of Sciences of the United States of America
S Dib-HajjS G Waxman

Abstract

Spinal sensory (dorsal root ganglion; DRG) neurons display slowly inactivating, tetrodotoxin-resistant (TTX-R), and rapidly inactivating, TTX-sensitive (TTX-S) Na currents. Attenuation of the TTX-R Na current and enhancement of TTX-S Na current have been demonstrated in cutaneous afferent DRG neurons in the adult rat after axotomy and may underlie abnormal bursting. We show here that steady-state levels of transcripts encoding the alpha-SNS subunit, which is associated with a slowly inactivating, TTX-R current when expressed in oocytes, are reduced significantly 5 days following axotomy of DRG neurons, and continue to be expressed at reduced levels, even after 210 days. Steady-state levels of alpha-III transcripts, which are present at low levels in control DRG neurons, show a pattern of transiently increased expression. In situ hybridization using alpha-SNS- and alpha-III-specific riboprobes showed a decreased signal for alpha-SNS, and an increased signal for alpha-III, in both large and small DRG neurons following axotomy. Reduced levels of alpha-SNS may explain the selective loss of slowly inactivating, TTX-R current. The abnormal electrophysiological properties of DRG neurons following axonal injury thus appear to reflect a...Continue Reading

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Citations

Jul 9, 1999·Journal of Neuroscience Research·J FjellJ A Black
Nov 26, 2002·Annals of Neurology·Matthew J CranerStephen G Waxman
Jan 27, 2010·Pflügers Archiv : European journal of physiology·Angelika LampertAndreas Leffler
Oct 11, 2011·Current Neurology and Neuroscience Reports·Ron Dabby
Mar 31, 2005·Molecular and Cellular Neurosciences·Chuanju LiuSulayman D Dib-Hajj
May 15, 2002·Brain Research. Molecular Brain Research·J A BlackS G Waxman
Feb 5, 1998·Brain Research. Molecular Brain Research·A L Oaklander, A J Belzberg
Feb 13, 1999·Progress in Neurobiology·M J Millan
Jan 22, 2000·Brain Research Bulletin·S G Waxman, J N Wood
Nov 20, 2001·Current Opinion in Pharmacology·C D Benham
Dec 21, 2010·Brain : a Journal of Neurology·Mihai MoldovanChristian Krarup
Oct 4, 2006·Current Opinion in Anaesthesiology·M S Gold
Apr 7, 2010·Annual Review of Neuroscience·Sulayman D Dib-HajjStephen G Waxman
Apr 1, 1999·Annual Review of Physiology·E W McCleskey, M S Gold
Mar 14, 2012·Marine Drugs·Francisco Rafael NietoCruz Miguel Cendán
Mar 24, 2011·Future Medicinal Chemistry·Elena ColomboPaolo Pevarello
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·S G WaxmanJ A Black
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·F PorrecaJ C Hunter

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