PMID: 9427516Jan 14, 1998Paper

Down-regulation of voltage-dependent sodium channels coincides with a low expression of alphabeta1 subunit complexes

Brain Research. Molecular Brain Research
G AlcarazB Dargent

Abstract

The association between the beta1 subunit and the alpha subunit of the sodium channel from rat brain was studied in hippocampus during postnatal development and in cultures of fetal rat forebrain neurons and cerebellar granule cells, using an anti-beta1 antipeptide antibody to specifically immunoprecipitate alphabeta1 complexes labeled with [3H]saxitoxin. In the hippocampus, the increase in beta1 RNA expression during development was accompanied by an increase in immunoprecipitated alphabeta1 complexes. Most of the alphabeta1 complexes were constituted during the first 3 postnatal weeks, with the steepest rise between postnatal days 5 and 12. In cultured fetal neurons, the amount of beta1 RNA and of alphabeta1 complexes was approximately 3-4% of that found in the adult, whereas it reached 60-70% in cultured cerebellar granule cells. We had previously described a neurotoxin-induced internalization of sodium channels which occurred in immature neurons but not in adult tissue. Internalization decreased during development in neurotoxin-treated hippocampal slices, and resistance of plasma membrane sodium channels to internalization followed the same time course than the appearance of alphabeta1 complexes. Similarly, neurotoxin activ...Continue Reading

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Citations

May 29, 1998·Brain Research. Molecular Brain Research·P GiraudB Dargent
Oct 3, 1998·The European Journal of Neuroscience·A Levy-MozziconacciA Autillo-Touati
Mar 29, 2000·Proceedings of the National Academy of Sciences of the United States of America·B SampoB Dargent
Feb 15, 2001·American Journal of Physiology. Cell Physiology·A D ShcherbatkoP Brehm

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