Downloadable computer models for renal replacement therapy

Kidney International
J L WaltherTimothy W Meyer

Abstract

Mathematical models can predict solute clearances and solute concentrations during renal replacement therapy. At present, however, most nephrologists cannot use these models because they require mathematical software. In this report, we describe models of solute transport by convection and diffusion adapted to run on the commonly available software program Excel for Macintosh computers and PCs running Windows. Two programs have been created that can be downloaded from http://www.stanford.edu/~twmeyer/ or http://dev.satellitehealth.com/research/journal.asp. The first, called 'Dr Addis Clearance Calculator', calculates clearance values from inputs including the blood flow Q(b), the hematocrit, the ultrafiltration rate Q(f), the dialysate flow rate Q(d), the reflection coefficient sigma and the mass transfer area coefficient K(o)A for the solute of interest, and the free fraction f if the solute is protein bound. Solute concentration profiles along the length of the artificial kidney are displayed graphically. The second program, called 'Dr Coplon Dialysis Simulator', calculates plasma solute concentrations from the clearance values obtained by the first program and from additional input values including the number of treatments p...Continue Reading

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Citations

Jan 11, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tammy L SirichTimothy W Meyer
Sep 21, 2011·Seminars in Dialysis·Timothy W MeyerThomas H Hostetter
Aug 8, 2008·Artificial Organs·Diana C DinhTimothy W Meyer
Oct 30, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Ilian O MarquezTimothy W Meyer
Sep 22, 2006·Kidney International·M R Marshall, T A Golper
Nov 2, 2016·Journal of the American Society of Nephrology : JASN·Timothy W MeyerThomas H Hostetter
Feb 14, 2012·Computer Methods and Programs in Biomedicine·Jung Chan LeeHee Chan Kim
Sep 6, 2017·Scientific Reports·Vaibhav MaheshwariPeter Kotanko
Oct 12, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·John K LeypoldtBernd Krause
Jan 26, 2007·Journal of the American Society of Nephrology : JASN·Timothy W MeyerThomas H Hostetter
Feb 16, 2007·Journal of the American Society of Nephrology : JASN·Thomas Depner, Jonathan Himmelfarb
Aug 26, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Tammy L SirichTimothy W Meyer
May 31, 2017·Seminars in Dialysis·Tammy L Sirich
Mar 17, 2015·Therapeutic Drug Monitoring·Stefanie KraffUlrich Jaehde
Nov 15, 2019·Morphologie : Bulletin De L'Association Des Anatomistes·S Randall Thomas

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