PMID: 9531977Apr 9, 1998Paper

Downregulated expression of the signaling molecules Nck, c-Crk, Grb2/Ash, PI 3-kinase p110 alpha and WRN during fibroblast aging in vitro

Biochimica Et Biophysica Acta
K Matuoka, T Takenawa

Abstract

An RT-PCR analysis was performed to examine changes in intracellular signal transducing molecules during in-vitro aging of human fibroblasts. Expression of Nck, c-Crk, Grb2/Ash, phosphoinositide (PI) 3-kinase p110 alpha and Werner's syndrome gene product WRN was noticeably reduced in late passage cells, showing a concurrent downregulation of a set of signaling molecules accompanying aging.

References

Dec 1, 1984·Cell Structure and Function·K MatuokaS Murota
Feb 16, 1995·Nature·T Pawson
Jul 28, 1995·Biochimica Et Biophysica Acta·P J Vojta, J C Barrett
Apr 12, 1996·Science·C E YuG D Schellenberg
Feb 7, 1997·Cell·T Hunter

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Citations

Jul 10, 2003·Archives of Gerontology and Geriatrics·Koozi MatuokaTadaomi Takenawa
Sep 22, 2010·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jacek PolosakMonika Puzianowska-Kuznicka
Mar 4, 2008·BMC Cardiovascular Disorders·Elena CastroLuis I Angel-Chávez
Oct 3, 1999·The Journal of Biological Chemistry·G BlanderM Oren
Jul 27, 2000·Annals of the New York Academy of Sciences·J O NehlinV A Bohr

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