Downregulated MALAT1 relates to recurrent pregnancy loss via sponging miRNAs

The Kaohsiung Journal of Medical Sciences
Yan WangJian-Jun Zhang

Abstract

Recurrent pregnancy loss (RPL) is three or more times of consecutive spontaneous loss of pregnancy. The underlying cause is complicated and the etiology of over 50% of RPL patients is unclear. Metastasis associated lung adenocarcinoma transcript-1 (MALAT-1), a multiple lncRNA functions as key regulators of diverse cellular processes. In this study, we found a reduced MALAT1 level in the villus samples of 36 RPL patients. Predicted by bioinformatics tool and confirmed by dual luciferase assay, we identified that MALAT1 directly interacts with miRNAs. Subsequent functional study in HTR-8/SVneo and HUVEC cells indicated that MALAT1 modulates the cell proliferation, apoptosis, migration and invasion via directly interact with miR-383, miR-15, miR-205 and miR-375. By modulating the VEGFA expression, MALAT1 controls the capillary formation of HUVEC cells. In conclusion, MALAT1 as a functional lncRNA controls cell proliferation, apoptosis, migration, invasion and modulates blood vessel formation. Down regulated MALAT1 induced disordered cross-talk between embryo and mother is one of the factor contributes to the pathogenesis of RPL.

References

May 1, 1989·Southern Medical Journal·J H Friedman
Jan 31, 2006·Cancer Science·Kazumi YamadaMasayuki Noguchi
Jun 6, 2009·Cell Death and Differentiation·R I AqeilanC M Croce
Jan 13, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jean-Francois MouilletYoel Sadovsky
Jun 22, 2012·RNA·Shinichi NakagawaKannanganattu V Prasanth
Jul 21, 2012·International Journal of Cancer. Journal International Du Cancer·Jaroslaw SzczyrbaFriedrich A Grässer
Jan 19, 2013·Cell Death & Disease·D GuanJ C Izpisua Belmonte
Feb 26, 2013·Journal of Reproductive Immunology·Myriam Hemberger
Mar 7, 2013·Genetics·Johnny T Y KungJeannie T Lee
Sep 24, 2013·Frontiers in Genetics·Marie van Dijk, Cees Oudejans
Jan 17, 2014·Nature·Yvonne TayPier Paolo Pandolfi
Mar 8, 2014·Circulation Research·Katharina M MichalikStefanie Dimmeler
Dec 3, 2014·Biochemical and Biophysical Research Communications·Zhou XuQianxue Chen
May 16, 2015·Clinical Epigenetics·Pedro Costa-PinheiroCarmen Jerónimo

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Citations

Jan 30, 2021·The Kaohsiung Journal of Medical Sciences·Miao-Miao WangYuan-Yuan Xiang
Apr 4, 2021·International Journal of Molecular Sciences·Jeong Yong LeeNam Keun Kim
Sep 4, 2021·Reproductive Biomedicine Online·Ai-Hua WuXue-Fang Liang
Nov 27, 2021·Wiley Interdisciplinary Reviews. RNA·Neha JainBibekanand Mallick
Dec 9, 2021·Molecular Medicine Reports·Zhuhua CaiXiaohui Deng

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