Downregulated miR-17, miR-29c, miR-92a and miR-214 may be related to BCL11B overexpression in T cell acute lymphoblastic leukemia.

Asia-Pacific Journal of Clinical Oncology
Zifan HeYangqiu Li

Abstract

BCL11B overexpression is a characteristic of most T cell acute lymphoblastic leukemia (T-ALL) cases, and downregulated BCL11B in leukemic T cells inhibits cell proliferation and induces apoptosis. The purpose of this study was to analyze the miRNA expression pattern that may be related to BCL11B regulation in T-ALL. Quantitative real-time PCR was used to detect the miRNAs miR-17-3p, miR-17-5p, miR-29c-3p, miR-92a-3p, miR-214-3p and miR-214-5p, the BCL11B expression level in peripheral blood mononuclear cells which was obtained from 17 de novo and untreated T-ALL patients, and 15 healthy individuals (HIs) served as control. Correlations between the relative miRNA expression levels and BCL11B were analyzed. Based on the computational prediction that certain miRNAs bind the BCL11B 3'-UTR, miR-17-3p, miR-17-5p, miR-29c-3p, miR-92a-3p, miR-214-3p and miR-214-5p were found to be candidates for regulating BCL11B. The expression levels of the six miRNAs were decreased compared with HIs, and with the exception of miR-17-5p, statistically significant differences in expression levels were found in the T-ALL group. Moreover, while significantly higher BCL11B expression was found in the T-ALL group, a negative trend in the correlation level...Continue Reading

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Citations

Apr 6, 2019·Journal of Cellular Physiology·Mohsen AlizadehBehzad Baradaran
Sep 12, 2018·International Journal of Molecular Sciences·Jaqueline Carvalho de OliveiraMaría Sol Brassesco
Dec 18, 2019·Cellular & Molecular Biology Letters·Jing-Ran SunYa Zhang
Jun 26, 2021·Cancer Control : Journal of the Moffitt Cancer Center·Fang-Liang HuangChia-Ling Li

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