Downregulation of B regulatory cells and upregulation of T helper 1 cells in children with Gaucher disease undergoing enzyme replacement therapy.

Immunologic Research
Asmaa M ZahranKhalid I Elsayh

Abstract

Gaucher disease (GD) involves a broad spectrum of immunological cells, including T helper (Th) cells and regulatory B cells (Bregs), which function to resolve the immune response and inhibit excessive inflammation. This study aimed to explore T helper cells, B cells, and Bregs in GD children undergoing enzyme replacement therapy (ERT). Our study included 20 GD patients; six patients were categorized as type 1 and 14 as type 3 GD. All patients were on regular ERT. Twenty healthy children were enrolled as controls. All patients and controls were subjected to complete blood analysis, abdominal ultrasound, and flow cytometric detection of T helper cells, B cells, and Bregs. Despite undergoing ERT, CD4+ T helper lymphocytes and Bregs were still significantly lower in patients with GD compared with the controls. Th1 and B cells were more in the patients than in the healthy controls. Lower levels of Bregs were found in type 3, compared with type 1 patients. Increased platelet count was directly associated with increased levels of Bregs and lower levels of B cells. Elevated children's height was also accompanied by decreasing levels of Th1. Our results propose that ERT in GD is associated with partial improvement in immune status, and ...Continue Reading

References

Dec 1, 1988·American Journal of Hematology·G E MartiH R Gralnick
Aug 1, 1997·Blood Cells, Molecules & Diseases·C E HollakM H van Oers
Jul 2, 1999·Blood Cells, Molecules & Diseases·L LacerdaM de Sousa
Oct 7, 2004·Seminars in Hematology·Gregory M PastoresAnna Tylki-Szymańska
Dec 21, 2004·Blood Cells, Molecules & Diseases·Ori RogowskiShlomo Berliner
Sep 9, 2005·The Journal of Experimental Medicine·Dawn M Jelley-GibbsSusan L Swain
Nov 21, 2007·Seminars in Immunology·Brigitta StockingerBruno Martin
Jul 25, 2008·Nature·Ruslan Medzhitov
Dec 20, 2008·Lancet·Gregory A Grabowski
Sep 10, 2009·International Immunology·Shimon SakaguchiTomoyuki Yamaguchi
Mar 23, 2010·Cell·Carl Nathan, Aihao Ding
Jul 30, 2010·Therapeutics and Clinical Risk Management·Ozlem Goker-Alpan
Oct 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Pramod K MistryMone Zaidi
Jan 10, 2012·Annual Review of Immunology·Claudia Mauri, Anneleen Bosma
Sep 14, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Abhishek DasMala K Maini
Feb 22, 2013·Science Translational Medicine·Fabian Flores-BorjaClaudia Mauri
Mar 21, 2013·Critical Reviews in Oncogenesis·Manoj Kumar Pandey, Gregory A Grabowski
Oct 2, 2013·Molecular Genetics and Metabolism·Manoj Kumar PandeyGregory A Grabowski
Nov 22, 2013·The Annals of Pharmacotherapy·Lunawati L Bennett, Devipriya Mohan
Aug 27, 2014·Blood Cells, Molecules & Diseases·Predrag RodicDragana Janic
Mar 31, 2015·The Cochrane Database of Systematic Reviews·Elad ShemeshTimothy M Cox
Jun 14, 2015·International Immunology·Claudia Mauri, Madhvi Menon
Jun 23, 2015·American Journal of Hematology·Joel Charrow, C Ronald Scott
Dec 18, 2015·Human Immunology·Marina Cadena MattaLeuridan Cavalcante Torres

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Methods Mentioned

BETA
flow cytometry
fluorescence-activated cell sorting

Software Mentioned

SPSS
CellQuest

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