Downregulation of c-jun results in apoptosis-mediated anti-osteosarcoma activity in an orthotopic model

Cancer Biology & Therapy
Crispin R DassPeter F M Choong

Abstract

c-jun has been found to be upregulated in a variety of cancers including osteosarcoma. DNAzymes are oligonucleotides capable of specific downregulation of target genes. c-jun knockdown-mediated apoptosis in osteosarcoma cells involved caspases-1, -2 and -8, but not the Fas/FasL pathway. A c-jun DNAzyme, encapsulated within a novel cationic multilamellar vesicle liposome, inhibited the growth and metastasis of osteosarcoma in an orthotopic spontaneously metastasising model of the disease. The 60 nm DDAB:DOPE liposome was formulated using ethanol injection/extrusion. Clinically, downregulation of c-jun may proffer an improved treatment outcome for these tumours originating in bone.

Citations

Feb 14, 2009·Cancer Metastasis Reviews·Hang T TaDave E Dunstan
Jun 30, 2010·Cancer Cell International·Jonathan Cm ClarkPeter Fm Choong
Mar 17, 2015·Expert Opinion on Biological Therapy·Alesya A FokinaJean-Christophe François
Feb 26, 2009·Expert Opinion on Drug Delivery·Mei Lin TanCrispin R Dass
Mar 13, 2010·Cancer Treatment Reviews·Marco Wachtel, Beat W Schäfer
Jan 19, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mei Lin TanCrispin R Dass
Dec 12, 2012·The Journal of Pharmacy and Pharmacology·Mei Lin TanCrispin R Dass
Jul 5, 2011·Chemical Biology & Drug Design·Mina Elahy, Crispin R Dass
Sep 19, 2015·Future Medicinal Chemistry·Shujun Fu, Lun-Quan Sun
May 14, 2014·Advanced Drug Delivery Reviews·Alejandro Sosnik, Angel M Carcaboso
Feb 26, 2010·Oligonucleotides·Crispin R DassPeter F M Choong
Feb 6, 2020·Frontiers in Oncology·Dhanasekhar ReddyRanjith Kumavath
Nov 15, 2011·DNA and Cell Biology·Soo-Hyun Kim, Crispin R Dass

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