Downregulation of cornulin in esophageal squamous cell carcinoma

Acta histochemica
Harsh PawarRekha Vijay Kumar

Abstract

Early events in the development of esophageal squamous cell carcinoma (ESCC) are poorly understood and many of the key molecules involved have not yet been identified. We previously used isobaric tags for a relative and absolute quantitation (iTRAQ)-based quantitative proteomics approach to identify differentially expressed proteins in ESCC tissue as compared to the adjacent normal mucosa. Cornulin was identified as one of the major downregulated molecules in ESCC. Cornulin is a member of the S100 fused-type protein family, which has an EF-hand calcium binding motif and multiple tandem repeats of specific peptide motifs. Cornulin was 5-fold downregulated in ESCC as compared to normal epithelium mirroring our previous findings in a gene expression study of ESCC. In the present study, we performed immunohistochemical validation of cornulin (CRNN) in a larger set of patients with ESCC. Downregulation of cornulin was observed in 89% (n=239) of 266 different ESCC tissues arrayed on tissue microarrays (TMAs). Expression of cornulin was observed in the prickle and functional cell layers of normal esophageal mucosa, localized predominantly in the cytoplasm and perinuclear region. The large majority of ESCC cases had little or no expres...Continue Reading

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Citations

Nov 23, 2013·The Journal of Thoracic and Cardiovascular Surgery·Po-Kuei HsuTeh-Ying Chou
Jan 21, 2016·TheScientificWorldJournal·Harsh PawarRekha V Kumar
Apr 8, 2015·Clinical Oral Investigations·Iman SalahshourifarRosnah Binti Zain
May 14, 2016·Translational Research : the Journal of Laboratory and Clinical Medicine·Federica CiregiaAntonio Lucacchini
Apr 23, 2019·Human Mutation·Eric D LarsonRegie Lyn P Santos-Cortez
Nov 6, 2020·Expert Review of Proteomics·Shobha DagamajaluT S Keshava Prasad

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