PMID: 9525009Apr 3, 1998Paper

Downregulation of cytokine-induced neutrophil chemoattractant and prolongation of rat liver allograft survival by interleukin-10

Surgery Today
X M ZouN Watanabe

Abstract

We investigated whether the administration of recombinant human interleukin-10 (rhIL-10) regulates the production of cytokine-induced neutrophil chemoattractant (CINC) and improves graft survival in rat orthotopic liver transplantation (OLTx). Allograft recipients received injections of rhIL-10 at doses of 2, 10, 20, or 50 micrograms/kg/day. The allograft recipients that received rhIL-10 at 10 or 20 micrograms/kg/day showed a slight but significant prolongation of graft survival to 13.0 +/- 0.4 and 13.8 +/- 0.3 days, respectively, compared with 9.6 +/- 0.2 days in untreated allografts. Conversely, the administration of high-dose rhIL-10 shortened the allograft survival. In the rhIL-10 treatment groups, the mean serum and tissue levels of CINC at every time point after OLTx were reduced significantly compared with those in the no-treatment group. The mean peak neutrophil counts in the peripheral circulation (PC) of the groups given rhIL-10 at 10, 20, or 50 micrograms/kg/day from the samples obtained 12h after reperfusion were decreased significantly compared with the no-treatment group. Furthermore, the mean peak neutrophil counts in the PC of the groups given rhIL-10 at 10 or 20 micrograms/kg/day from the samples obtained betwe...Continue Reading

Citations

Jul 1, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H YoshidomeA B Lentsch
Jan 30, 2004·Cytokine & Growth Factor Reviews·Simone MocellinMario Lise
Dec 20, 2000·Transplantation Proceedings·X M ZouB Zhang
Aug 16, 2002·Transplant Immunology·Annette Boehler
Mar 13, 2001·Annual Review of Immunology·K W MooreA O'Garra
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Yinghua TianPierre-Alain Clavien
Dec 19, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Hartmut Jaeschke
Apr 6, 2006·World Journal of Gastroenterology : WJG·Li-Juan Zhang, Xiao-Zhong Wang
Jan 31, 2002·World Journal of Gastroenterology : WJG·W J Dai, H C Jiang
Sep 28, 2017·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Jaroslaw PierógRalph A Schmid

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