Downregulation of dendritic I(h) in CA1 pyramidal neurons after LTP.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Emilie CampanacDominique Debanne

Abstract

Hyperpolarization-activated (h)-channels occupy a central position in dendritic function. Although it has been demonstrated that these channels are upregulated after large depolarizations to reduce dendritic excitation, it is not clear whether they also support other forms of long-term plasticity. We show here that nearly maximal long-term potentiation (LTP) induced by theta-burst pairing produced upregulation in h-channel activity in CA1 pyramidal neurons. In contrast, moderate LTP induced by spike-timing-dependent plasticity or high-frequency stimulation (HFS) downregulated the h-current (I(h)) in the dendrites. After HFS-induced LTP, the h-conductance (G(h)) was reduced without changing its activation. Pharmacological blockade of I(h) had no effect on LTP induction, but occluded EPSP-to-spike potentiation, an input-specific facilitation of dendritic integration. Dynamic-clamp reduction of G(h) locally in the dendrite mimicked the effects of HFS and enhanced synaptic integration in an input-selective way. We conclude that dendritic I(h) is locally downregulated after induction of nonmaximal LTP, thus facilitating integration of the potentiated input.

Citations

Sep 23, 2011·Pflügers Archiv : European journal of physiology·Warren D AndersonGermán Barrionuevo
Nov 26, 2013·Nature Neuroscience·Stephen R Williams
Aug 31, 2012·Journal of Neurophysiology·Rishikesh Narayanan, Daniel Johnston
Sep 30, 2009·PloS One·Jake Ormond, Melanie A Woodin
Apr 22, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·J Amiel Rosenkranz
Jan 29, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lin LinDax A Hoffman
Jan 28, 2014·Brain Research Bulletin·Darrin H Brager, Daniel Johnston
Feb 15, 2014·Neuroscience Bulletin·Yoon-Sil YangSung-Cherl Jung
Feb 10, 2016·Scientific Reports·Jeffrey Lopez-RojasMichael R Kreutz
Apr 24, 2014·The Journal of Physiology·Mala M Shah
Sep 9, 2009·The Journal of Physiology·Jean-Didier Breton, Greg J Stuart
Apr 7, 2010·Trends in Neurosciences·Mala M ShahDax A Hoffman
Nov 6, 2009·Trends in Neurosciences·Riccardo Mozzachiodi, John H Byrne
Mar 20, 2015·Journal of Neuroscience Research·Tomasz Wójtowicz, Jerzy W Mozrzymas
Dec 12, 2012·Epilepsy & Behavior : E&B·Yoav NoamGregory L Holmes
Jun 17, 2016·Journal of Neurophysiology·Zhen Yang, Fidel Santamaria
Oct 31, 2017·F1000Research·Gabriele Scheler
Apr 24, 2014·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Moon-Seok KangSung-Cherl Jung
Oct 1, 2009·The European Journal of Neuroscience·Benjamin HassfurthUrsula Koch
Jul 2, 2009·The Journal of Physiology·Dominique Debanne
Apr 30, 2011·Physiological Reviews·Dominique DebanneGisèle Alcaraz
Jun 16, 2018·Neurobiology of Learning and Memory·Timothy F MusialDaniel A Nicholson
Sep 21, 2019·Neurobiology of Learning and Memory·Dominique Debanne, Michaël Russier
Nov 5, 2013·Neuron·Karunesh Ganguly, Mu-Ming Poo

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