Downregulation of DHRS9 is associated with poor prognosis in oral squamous cell carcinoma

Pathology
Hiroyuki ShimomuraTadaaki Kirita

Abstract

Oral squamous cell carcinoma (OSCC) has a high potential for local invasion and nodal metastasis. Therefore, early detection and elucidation of the detailed molecular mechanisms underlying OSCC are essential. Dehydrogenase/reductase member 9 (DHRS9) is downregulated in recurrent OSCC. Although DHRS9 is reported to act as a tumour suppressor in several malignancies, its expression in OSCC cells is unknown. In this study, we examined DHRS9 expression immunohistochemically in specimens from a sample of 98 OSCC patients. Reduced DHRS9 expression was observed in 68 of 98 patients (69.4%) with OSCC. A significant association was found between low DHRS9 expression and local progression (T factor) (p = 0.0135). Furthermore, patients with low DHRS9 expression had a significantly poorer prognosis than those with high DHRS9 expression (p = 0.0443). In multivariate analysis using the Cox proportional hazards model, decreased DHRS9 expression strongly correlated with worse prognosis. The study findings suggest that DHRS9 might be a useful diagnostic and prognostic marker for OSCC.

References

Jan 17, 2007·British Journal of Cancer·C W M ReuterA Eckardt
Aug 1, 2007·Pharmaceutical Research·Narin ChansriMitsuru Hashida
Sep 23, 2008·Oral Oncology·Hidenori SuzukiTsuneo Tamaki
Sep 23, 2011·Oral Oncology·Mario Pérez-SayánsAbel García-García
Aug 23, 2012·Biochemical and Biophysical Research Communications·Young-Ju Woo, Kyung Lib Jang
Mar 7, 2014·Pathology Oncology Research : POR·Ekaterina S KropotovaTamara D Mashkova
Mar 26, 2014·International Journal of Clinical Oncology·Tomonori SasahiraHiroki Kuniyasu
Aug 9, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Liang HuChun-Fang Gao
May 18, 2016·Virchows Archiv : an International Journal of Pathology·Tomonori SasahiraHiroki Kuniyasu
Jun 10, 2016·British Journal of Cancer·Tomonori SasahiraHiroki Kuniyasu
Oct 11, 2016·The New England Journal of Medicine·Robert L FerrisMaura L Gillison
Jan 12, 2017·CA: a Cancer Journal for Clinicians·Kevin D ShieldIsabelle Soerjomataram
Jan 10, 2018·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal

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Citations

Mar 1, 2019·Journal of Clinical Medicine·Miyako Kurihara-ShimomuraTadaaki Kirita
Aug 9, 2020·Cancer Management and Research·Huang-Bao LiLongsheng Xu
Jan 21, 2021·Nutrients·Helen B Everts, Eleonore-Nausica Akuailou

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